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Hyperpolarized 13C MRS- Redox Imaging and the Brain

Weekly Seminar | Not Open to the Public
Who Should Attend: 


David M. Wilson, M.D., Ph.D.
Associate Professor In Residence
Step 1 Radiology and Biomedical Imaging School of Medicine
University of California, San Francisco


The goal of research in the Wilson lab is to develop metabolism and microenvironment-targeted imaging methods, to guide intervention and predict response to molecular therapies. The lab develops cutting-edge magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques to study basic biochemical pathways and their alterations in cancer and other metabolic disorders. New chemistries are used in the design and synthesis of imaging probes, which have strong potential for translation into the clinic. We are particularly focused on the molecular imaging of antioxidants and reactive oxygen species that play a crucial role in the development and progression of disease.

David Meybin Wilson, M.D., Ph.D. Figure


Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM
[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Chem Commun (Camb). 2016 Apr 7;52(27):4888-90. doi: 10.1039/c6cc00895j. Epub 2016 Mar 10.
Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM
Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
Bioconjug Chem. 2016 Jan 20;27(1):170-8. doi: 10.1021/acs.bioconjchem.5b00584. Epub 2015 Dec 22.


Tuesday, March 20, 2018 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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