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Histone Deacetylase-3: Friend and Foe of the Brain

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Histone deacetylases (HDACs) are a group of enzymes that deacetylate lysine residues on histones and many other proteins in the nucleus, cytoplasm and mitochondria.  Structurally distinct pharmacological inhibitors of HDACs inhibit neuronal death in cell culture and in vivo models of a variety neurodegenerative diseases. However, the identity of the HDAC(s) that are abnormally activated in neurodegenerative diseases and targeted by the inhibitors to affort protection has been unclear because of the non-selectivity of the inhibitors with regard to the different HDAC isoforms. In my presentation I will present evidence indicating that HDAC3 is a central player in the promotion of neuronal death. Neurotoxicity by HDAC3 depends on its phosphorylation and interaction with HDAC1.  While promoting death of mature neurons, HDAC3 is required for normal brain development acting as a key regulator of distinct neurodevelopmental events. Evidence demonstrating the requirement for HDAC3 in brain development will be presented.

Dr. D’Mello's Figure


Farah H Bardai, Santosh R D'Mello
Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3beta
J Neurosci, 31 (5), 1746-51 2011 Feb 2
Farah H Bardai, Pragya Verma, Chad Smith, Varun Rawat, Lulu Wang, Santosh R D'Mello
Disassociation of Histone deacetylase-3 From Normal Huntingtin Underlies Mutant Huntingtin Neurotoxicity
J Neurosci, 33 (29), 11833-8 2013 Jul 17
Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim, Santosh R D'Mello
The Bdnf and Npas4 Genes Are Targets of HDAC3-mediated Transcriptional Repression
BMC Neurosci, 20 (1), 65 2019 Dec 28


Tuesday, March 3, 2020 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.