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Gamma Oscillations: Mechanisms, Function and Human Diseases

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Rhythmic neural activity in the gamma range (30-80 Hz) is modulated during various aspects of cognitive function and is disrupted in several neurological conditions, including Alzheimer's disease (AD). It is well established that sensory stimuli can induce local network oscillations at specific frequencies in cortical regions. We have applied this approach, which we term Gamma ENtrainment Using Sensory stimuli (GENUS), using patterned light and sound stimulation at 40 Hz in AD model mice. We showed GENUS augmented gamma power in multiple brain regions. Moreover, daily application markedly reduced amyloid and tau pathology, attenuated degeneration of neurons and synapses, and improved cognitive function in multiple AD mouse models. In addition, GENUS induced morphological and gene expression changes of various cell types, including microglia and enhanced vasodilation. We extended these findings to evaluate the therapeutic potential of GENUS in human AD, and decipher the underlying cellular and physiological mechanisms of GENUS. In humans, GENUS promoted 40 Hz brain rhythms in cortical and subcortical brain regions, stabilized hippocampal volume in AD subjects, and maintained functional connectivity in the brain in pilot clinical studies. Our recent investigation has revealed that GENUS facilitates cerebral spinal fluid (CSF) influx and modifies meningeal lymphatic vasculature. Surprisingly, we found that depletion of microglia in AD model mice augmented the neuroprotective effects of GENUS. I will discuss our latest work aiming to decipher the mechanism underlying the effects of GENUS on ameliorating AD pathology and symptoms.

Dr. Li Huei Tsai's Figure


Hannah F Iaccarino, Annabelle C Singer, Anthony J Martorell, Andrii Rudenko, Fan Gao, Tyler Z Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G Canter, Richard Rueda, Emery N Brown, Edward S Boyden, Li-Huei Tsai
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Nature. 2016 Dec 7;540(7632):230-235. doi: 10.1038/nature20587.
Anthony J Martorell, Abigail L Paulson, Ho-Jun Suk, Fatema Abdurrob, Gabrielle T Drummond, Webster Guan, Jennie Z Young, David Nam-Woo Kim, Oleg Kritskiy, Scarlett J Barker, Vamsi Mangena, Stephanie M Prince, Emery N Brown, Kwanghun Chung, Edward S Boyden, Annabelle C Singer, Li-Huei Tsai
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition
Cell. 2019 Apr 4;177(2):256-271.e22. doi: 10.1016/j.cell.2019.02.014. Epub 2019 Mar 14.
Chinnakkaruppan Adaikkan, Steven J Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z Young, Ho-Jun Suk, Edward S Boyden, Thomas J McHugh, Li-Huei Tsai
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection
Neuron. 2019 Jun 5;102(5):929-943.e8. doi: 10.1016/j.neuron.2019.04.011. Epub 2019 May 7.


Tuesday, May 24, 2022 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.

Research Methods: 
Gene Expression