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FAIR Data Sharing for Discovery and Translation in CNS Injury

Weekly Seminar
Who Should Attend: 


Guest Speaker
Adam R. Ferguson, Ph.D.
Associate Professor and Principal Investigator
Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery
University of California, San Francisco (UCSF)
Principal Investigator
San Francisco VA Medical Center

My research focuses on mechanisms of recovery after neurological trauma. Injuries to the brain and spinal cord invoke numerous, interacting biological processes that work in concert to determine recovery success. Some of these biological processes have contradictory effects at different phases of recovery. For example, mechanisms of synaptic regulation can contribute to cell death in the early phases of recovery but may promote plasticity and restoration of function at later stages. Understanding the mechanisms of recovery in the complex microenvironment of the injured central nervous system (CNS) requires large-scale integration of biological information and functional outcomes (i.e., biomedical informatics). Our work uses a combination of laboratory studies and ‘big-data’ approaches to provide an information-rich picture of the syndrome produced by trauma in translational in vivo models. The long-term goal of this research is to provide system-level therapeutic targets for enhancing recovery of function after brain and spinal injury.

Adam R. Ferguson, Ph.D. Figure


Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine KA, Gensel JC, Kloke J, Petrossian TC, Lum PY, Carlsson GE, Manley GT, Young W, Beattie MS, Bresnahan JC, Ferguson AR.
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury.
Nat Commun. 2015 Oct 14;6:8581. doi: 10.1038/ncomms9581.
Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Nout-Lomas YS, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH.
Restorative effects of human neural stem cell grafts on the primate spinal cord.
Nat Med. 2018 May;24(4):484-490. doi: 10.1038/nm.4502. Epub 2018 Feb 26.
Huie JR, Diaz-Arrastia R, Yue JK, Sorani MD, Puccio AM, Okonkwo DO, Manley GT, Ferguson AR; TRACK-TBI Investigators.
Testing a Multivariate Proteomic Panel for Traumatic Brain Injury Biomarker Discovery: A TRACK-TBI Pilot Study.
J Neurotrauma. 2018 Sep 27. doi: 10.1089/neu.2017.5449. [Epub ahead of print]


Tuesday, November 13, 2018 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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