Energy Restitution as a Therapeutic Strategy for Alzheimer’s Disease

EVENT:

Weekly Seminar | Not Open to the Public

Host:

Gary E. Gibson, Ph.D.

Who Should Attend:

Researchers

Event Flyer:

seminar-eugenia-trushina-061819.pdf

Speakers

Eugenia Trushina, Ph.D.

Professor of Neurology, Associate Professor of Pharmacology, Director

Mitochondrial Neurobiology and Therapeutics Laboratory

Mayo Clinic

Abstract

Dr. Trushina is a Professor in the Department of Neurology and the Department of Molecular Pharmacology and Experimental Therapeutics at the Mayo Clinic Rochester. She received her doctoral degree in organic chemistry from Saratov State University in Russia. Dr. Trushina completed her postdoctoral training at the Mayo Clinic, Rochester studying redox chemistry related to nitric oxide and mechanisms of mitochondrial dynamics and function in Huntington’s Disease. Dr. Trushina translational research program is focused on the mechanisms of neurodegenerative diseases, particularly as they intersect with studies on aging and metabolic disorders, and the development of mitochondria-targeted therapeutics. Her group developed neuroprotective treatment for Alzheimer’s Disease, which is now in the lead optimization and preclinical characterization stage. Dr. Trushina is a recipient of the NIH NINDS, NIA, NIEHS, BrightFocus, GHR, ADDF, and Mayo Clinic Research Awards.

Dr. Trushina's Diagram

Publications

Zhang L, Trushin S, Christensen TA, Tripathi U, Hong C, Geroux RE, Howell KG, Poduslo JF, Trushina E.

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.

Neurobiol Dis. 2018 Jun;114:1-16. doi: 10.1016/j.nbd.2018.02.003. Epub 2018 Mar 2.

Zhang L, Trushin S, Christensen TA, Bachmeier BV, Gateno B, Schroeder A, Yao J, Itoh K, Sesaki H, Poon WW, Gylys KH, Patterson ER, Parisi JE, Diaz Brinton R, Salisbury JL, Trushina E.

Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.

Sci Rep. 2016 Jan 5;6:18725. doi: 10.1038/srep18725.

Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E.

Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease.

EBioMedicine. 2015 Apr 1;2(4):294-305. Erratum in: EBioMedicine. 2019 Apr;42:532.