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Deciphering Corticospinal Circuits in Controlling Touch and Tactile Neuropathic Pain Sensitivity

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Descending supraspinal pathways integrate signals from multiple brain regions and are the neural basis by which our brain controls our body. As yet, the design principles for such top-down control remain elusive. The mission of our lab is: (1) To decipher supraspinal circuits in somatosensory perception. (2) To investigate the underlying mechanisms of top-down control in chronic pain states. To achieve these goals, we will use a multidisciplinary approach combining intersectional viral-mediated gene manipulation, in vivo imaging, and electrophysiological and single-cell sequencing techniques. Ultimately, our research will help explain how our mental states directly alter normal and pathological somatosensory perception in different contexts or mood states, and will uncover potential targets for treating pain.

Dr. Kevin Liu's Figure


Yuanyuan Liu, Shane Hegarty, Carla Winter, Fan Wang, Zhigang He
Viral vectors for neuronal cell type-specific visualization and manipulations
Curr Opin Neurobiol. 2020 Aug;63:67-76. doi: 10.1016/j.conb.2020.03.011. Epub 2020 Apr 25.
Yuanyuan Liu, Alban Latremoliere, Xinjian Li, Zicong Zhang, Mengying Chen, Xuhua Wang, Chao Fang, Junjie Zhu, Chloe Alexandre, Zhongyang Gao, Bo Chen, Xin Ding, Jin-Yong Zhou, Yiming Zhang, Chinfei Chen, Kuan Hong Wang, Clifford J Woolf, Zhigang He
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Nature. 2018 Sep;561(7724):547-550. doi: 10.1038/s41586-018-0515-2. Epub 2018 Sep 12.
Xuhua Wang, Yuanyuan Liu, Xinjian Li, Zicong Zhang, Hengfu Yang, Yu Zhang, Philip R Williams, Noaf S A Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R Gerfen, Kuan Hong Wang, Zhigang He
Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills
Cell. 2017 Oct 5;171(2):440-455.e14. doi: 10.1016/j.cell.2017.08.014. Epub 2017 Sep 21.


Tuesday, October 5, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Pain and Sensory Recovery Icon
Pain free, touch and smell like before.
Motor Recovery Icon
Write and walk again.
Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.

Research Methods: 
In Vivo Imaging, Gene Expression