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Creating New Myelin in the Brain: A Mechanism for Plasticity and Repair

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Abstract 

The cerebral cortex contains axons from a highly diverse population of neurons that exhibit distinct and often discontinuous myelination. Time lapse, in vivo two photon imaging has revealed that both the length and position of myelin sheaths along individual axons are remarkably stable (Hughes et al., 2018), suggesting that maintaining the precise pattern of myelin is important for cortical function. In the relapsing-remitting stages of multiple sclerosis and in the cuprizone model of demyelination in mice, myelin is restored through the regeneration of oligodendrocytes by endogenous oligodendrocyte precursor cells (OPCs). However, it is unknown whether this robust regenerative process restores the original pattern of myelination. To address this question, we examined the time course of oligodendrocyte loss and regeneration in the somatosensory cortex using longitudinal in vivo two-photon imaging through a cranial window in Mobp-EGFP transgenic mice, in which oligodendrocytes and their complement of myelin sheaths can be resolved. These longitudinal studies of cortical remyelination suggest that there are significant constraints on formation of new oligodendrocytes and restoration of specific myelin sheaths after a demyelinating event. Reorganization of myelin patterns in cortical circuits may alter sensory processing and contribute to cognitive decline in demyelinating disease.

Dr. Bergles' Figure

Publications

Ethan G Hughes, Jennifer L Orthmann-Murphy, Abraham J Langseth, Dwight E Bergles
Myelin Remodeling Through Experience-Dependent Oligodendrogenesis in the Adult Somatosensory Cortex
Nat Neurosci, 21 (5), 696-706 May 2018
Valerie A Larson, Yevgeniya Mironova, Kimberly G Vanderpool, Ari Waisman, John E Rash, Amit Agarwal, Dwight E Bergles
Oligodendrocytes Control Potassium Accumulation in White Matter and Seizure Susceptibility
Elife, 7 2018 Mar 29
Leslie Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D Smith, Kyle A Martin, Jingya Wang, Hayley Strasburger, Leyla Herbst, Maya Alexis, Jodi Karnell, Todd Davidson, Ranjan Dutta, Joan Goverman, Dwight Bergles, Peter A Calabresi
Oligodendrocyte Precursor Cells Present Antigen and Are Cytotoxic Targets in Inflammatory Demyelination
Nat Commun, 10 (1), 3887 2019 Aug 29

When

Tuesday, February 25, 2020 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Research Methods