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Contributions of Reactive Astrocytes to Alzheimer’s Disease Progression

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Speakers

Speaker headshot
Assistant Professor
Neurology
Massachusetts General Hospital Harvard Medical School

Abstract

Astrocytes suffer profound molecular, functional, and morphological changes in Alzheimer’s disease (AD), collectively termed reactive astrogliosis. Reactive astrocytes surround the two pathological hallmarks of AD—amyloid-b (Ab) plaques and tau neurofibrillary tangles—but their role in AD progression remains controversial. Specifically, whether reactive astrocytes protect neurons and synapses from the toxic effects of Ab and tau aggregates, or acquire neurotoxic properties and contribute to neurodegeneration, or merely accompany the neurodegenerative process as bystanders has yet to be elucidated. We will discuss recent data from our lab highlighting the complexity of the reactive astrogliosis observed in AD.PDF icon graphical_abstract_asp.pdf

Publications

2. Muñoz-Castro C*, Noori A*, Magdamo CG, Li Z, Marks JD, Frosch MP, Das S, Hyman BT, Serrano-Pozo A.
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease.
Journal of Neuroinflammation
3. Jaisa-aad M, Muñoz-Castro C, Healey MA, Hyman BT, Serrano-Pozo A.
Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer’s disease and related dementias.
Acta Neuropathologica

When

Tuesday, May 28, 2024 - 12:30pm

Where

Conference Room: 
Billings Building – Rosedale

More Information

Darlene White