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Come fly with me – what Drosophila can tell us about neurodegenerative disease

Weekly Seminar | Not Open to the Public
Who Should Attend: 
Event Flyer: 
PDF icon zarnescu_4-16-24.pdf


Daniela C. Zarnescu, Ph.D.
Associate Dean of Graduate Education and Postdoctoral Training Professor
Cellular and Molecular Physiology
Penn State College of Medicine


Research abstract: We study the molecular mechanisms of aging and neurodegenerative diseases with a focus on RNA processing and cellular metabolism. We use a combination of molecular, genetic, bioinformatic and pharmacological tools, and a diverse array of experimental models, including fruit flies, cultured cells and patient tissues. We also seek to develop therapeutics for neurodegenerative disorders. I will present our recent findings on modelling TDP-43 proteinopathies in ALS and FTD relevant circuits with a focus on metabolic, synaptic and signaling targets.PDF icon zarnescu_lab_research_summary.pdf


Manzo, E*, Lorenzini I, Barrameda D#, O’Conner AG#, Barrows JM#, Starr A, Kovalik T, Lehmkuhl E.M.*, Shreiner DD, Joardar A, Liévens J-C, Bowser R, Sattler R, Zarnescu D.C.
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.
eLife 2019 Jun 10;8. pii: e45114. doi: 10.7554/eLife.45114. PMID: 31180318
Lehmkuhl, E.M.*, Loganathan, S.*, Alsop, E., Blythe, A.D., Kovalik, T., Mortimore, N.P. #, Barrameda, D. #, Kueth, C., Eck, R.J. #, Siddegowda, B.B.o, et al.
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Acta Neuropathologica Communications
R Keating Godfreyo, Eric Alsop, Reed T Bjork*, Brjesh S Chauhano, Hillary C Ruvalcaba#, Jerry Antone, Lauren M Gittings, Allison F Michael*, Christi Williams*, Grace Hala’ufia#, Alexander D Blythe*, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C Zarnescu
Modelling dementia in Drosophila uncovers shared and specific targets of TDP-43 proteinopathy across ALS and FTD relevant circuits.
Acta Neuropathologica Communications


Tuesday, April 16, 2024 - 12:30pm


Conference Room: 
Billings Building – Rosedale

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Darlene White