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Cancer Related Cognitive Dysfunction – An Update

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. James Root's Photo
Associate Attending Neuropsychologist - Neurocognitive Research Lab
Department of Psychiatry and Behavioral Sciences


As the population of cancer survivors has grown into the millions, there has been increasing emphasis on understanding how the late effects of treatment affect survivors’ ability to return to work/school, their capacity to function and live independently, and their overall quality of life. This presentation focuses on cognitive change associated with cancer and cancer treatments. Research in this area has progressed from a pharmacotoxicology perspective to a view of the cognitive change as a complex interaction of aspects of the treatment, vulnerability factors that increase risk for posttreatment cognitive decline, cancer biology, and the biology of aging. Conceptual issues that arise from this multidimensional perspective are described in relation to future directions, understanding of mechanisms, and development of innovative interventions.


James C Root, Denise Pergolizzi, Hong Pan, Irene Orlow, Steven D Passik, David Silbersweig, Emily Stern, Tim A Ahles
Prospective evaluation of functional brain activity and oxidative damage in breast cancer: changes in task-induced deactivation during a working memory task
Brain Imaging Behav. 2020 Jul 24;10.1007/s11682-020-00335-1. doi: 10.1007/s11682-020-00335-1. Online ahead of print.
James C Root, Claudine Campbell, Xiomara Rocha-Cadman, Nicole Kasven-Gonzalez, Molly Maloy, Jessica Flynn, Sean M Devlin, Ann A Jakubowski
Pretransplantation Cognitive Dysfunction in Advanced-Age Hematologic Cancers: Predictors and Associated Outcomes
Biol Blood Marrow Transplant. 2020 Aug;26(8):1497-1504. doi: 10.1016/j.bbmt.2020.05.010. Epub 2020 May 21.
James C Root, Charissa Andreotti, Loretta Tsu, Timothy M Ellmore, Tim A Ahles
Learning and memory performance in breast cancer survivors 2 to 6 years post-treatment: the role of encoding versus forgetting
J Cancer Surviv. 2016 Jun;10(3):593-9. doi: 10.1007/s11764-015-0505-4. Epub 2015 Dec 12.


Tuesday, March 23, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.
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Remember and speak clearly.