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Astrocytes as Context-Specific Regulators of Memory in Health and Disease

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Anna Orr's Photo
Nan and Stephen Swid Assistant Professor of Frontotemporal Dementia Research and Assistant Professor of Neuroscience


Dr. Orr will discuss emerging studies showing that astrocytes are context-dependent regulators of behavior and cognitive function, including spatial memory. These studies suggest that aberrant changes in astrocytic signaling in aging or disease promote selective and sex-specific neural deficits and represent novel therapeutic targets for various CNS disorders. Dr. Orr will also highlight new findings that astrocytic proteinopathy associated with dementia can induce memory loss through selective changes in astrocytic neuroimmune pathways and synaptic functions. Together, these studies are redefining astrocytes as precise neural modulators in health and disease.

Dr. Anna Orr's Diagram


Anna G Orr, Edward C Hsiao, Max M Wang, Kaitlyn Ho, Daniel H Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, Anthony Adame, Nino Devidze, Dena B Dubal, Eliezer Masliah, Bruce R Conklin, Lennart Mucke
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Nat Neurosci. 2015 Mar;18(3):423-34. doi: 10.1038/nn.3930. Epub 2015 Jan 26.
Avital Licht-Murava, Samantha M. Meadows, Fernando Palaguachi, Soomin C. Song, Yaron Bram, Constance Zhou, Stephanie Jackvony, Robert E. Schwartz, Robert C. Froemke, Adam L. Orr, Anna G. Orr
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
BioRxiv Aug 30, 2022; 503668. In revision.
Samantha M. Meadows, Fernando Palaguachi, Avital Licht-Murava, Daniel Barnett, Till S. Zimmer, Constance Zhou, Samantha R. McDonough, Adam L. Orr, Anna G. Orr
Astrocytes regulate spatial memory in a sex-specific manner
BioRxiv Nov 3, 2022; 511881. Submitted.


Tuesday, December 13, 2022 - 12:30pm


Conference Room: 
Billings Building – Rosedale and Zoom

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.