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Astrocyte Cell-Cell Communication in Health and Disease

Who Should Attend: 
Event Flyer: 
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Professor of Neurology
Kuchroo Weiner Distinguished Professor of Neuroimmunology


Astrocytes perform diverse functions in health and disease. Astrocyte dysfunction is found in numerous diseases, including multiple sclerosis, Alzheimer disease, Parkinson disease, Huntington disease and neuropsychiatric disorders. Astrocytes regulate glutamate and ion homeostasis, cholesterol and sphingolipid metabolism and respond to environmental factors, all of which have been implicated in neurological diseases. Astrocytes also exhibit significant heterogeneity, driven by developmental programs and stimulus-specific cellular responses controlled by CNS location, cell-cell interactions and other mechanisms. In this presentation, we will discuss novel tools to study cell interactions, and how they can define cell-cell interaction mechanisms that control astrocyte function in health and disease, while illuminating candidate targets for therapeutic intervention.


Liliana M Sanmarco, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Federico Giovannoni, Giulia Scalisi, Evelyn S Heck, Moneera Alsuwailm, Burkhard Becher, Francisco J Quintana
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Nature . 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6.
Iain C Clark, Cristina Gutiérrez-Vázquez, Michael A Wheeler, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M Sanmarco, Lydia Guo, Manon Blain, Stephanie E J Zandee, Chun-Cheih Chao, Katelyn V Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W Shultis, Yasmin Salem, Emily C Tjon, Pedro H Fonseca-Castro, Davis M Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R Abate, Douglas L Rosene, Kevin J Hodgetts, Marco Prinz, Jack P Antel, Alexandre Prat, Francisco J Quintana
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
Science . 2021 Apr 23;372(6540):eabf1230. doi: 10.1126/science.abf1230.
Iain C Clark, Michael A Wheeler, Hong-Gyun Lee, Zhaorong Li, Liliana M Sanmarco, Shravan Thaploo, Carolina M Polonio, Seung Won Shin, Giulia Scalisi, Amy R Henry, Joseph M Rone, Federico Giovannoni, Marc Charabati, Camilo Faust Akl, Dulce M Aleman, Stephanie E J Zandee, Alexandre Prat, Daniel C Douek, Eli A Boritz, Francisco J Quintana, Adam R Abate
Identification of astrocyte regulators by nucleic acid cytometry
Nature . 2023 Feb;614(7947):326-333. doi: 10.1038/s41586-022-05613-0. Epub 2023 Jan 4.


Tuesday, April 11, 2023 - 12:30pm


Conference Room: 
Billings Building – Rosedale
Zoom Meeting

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Darlene White