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From Actin Dynamics to Membrane Trafficking: Intracellular Mechanism Controlling Astrocyte Reactivity and Scar Formation in the Brain

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Britta Eickholt's Photo
Director of Centrum and Group Leader Signaling Mechanisms in Brain Development and Disease


The nervous system lacks the ability to regenerate nerve cells and is therefore particularly vulnerable to injury. Following brain injury or infection, various cells have to work together in a coordinated manner in order to limit damage and enable recovery. 'Astrocytes', the most common type of glial cell found in the central nervous system, play a key role in the protection of surrounding tissues. They form part of a defence mechanism known as 'reactive astrogliosis', which facilitates scar formation, thereby helping to contain inflammation and control tissue damage. In my seminar, I will present our work describing how the actin cytoskeleton and intracellular membrane trafficking controls essential aspect of astrogliosis responses and how these cellular machineries are essential during scar formation. Our work encompasses biochemistry, cell biology (lots of live cell imaging!!) and in vivo manipulation in rodent models to test our mechanisms.

Dr. Britta Eickholt's Figure


Juliane Schiweck, Kai Murk, Julia Ledderose, Agnieszka Münster-Wandowski, Marta Ornaghi, Imre Vida, Britta J Eickholt
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking
Nat Commun. 2021 Mar 5;12(1):1490. doi: 10.1038/s41467-021-21662-x.
Patricia Kreis, Christian Gallrein, Eugenia Rojas-Puente, Till G A Mack, Cristina Kroon, Viktor Dinkel, Claudia Willmes, Kai Murk, Susanne Tom-Dieck, Erin M Schuman, Janine Kirstein, Britta J Eickholt
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w.
Juliane Schiweck, Britta J Eickholt, Kai Murk
Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease
Front Cell Neurosci. 2018 Aug 21;12:261. doi: 10.3389/fncel.2018.00261. eCollection 2018.


Tuesday, June 28, 2022 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Traumatic Brain Injury icon
In the U.S., over 5.3 million adults and children live with TBI.

Research Methods: 
In Vivo Imaging