Cho Lab
News & Impact

You are here

Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia

Journal Article
Wen Fury, Keun Woo Park, Zhuhao Wu, Eunhee Kim, Moon-sook Woo, Yu Bai, Lynn E. Macdonald, Susan D. Croll, Sunghee Cho
Year Published: 
Stroke. 2020 Jul 9;50. doi: 10.1161/STROKEAHA.120.029440
Full-Text on


By comprehensively profiled ~25,000 mouse genes across multiple phases after stroke, the study showed a key role for immune-related genes and contribution of peripheral immune cells trafficked into regions of the injured brain, even months after stroke. The significance of these studies is the demonstration of a previously unrecognized expansive and longer-lasting involvement of peripheral immunity on stroke pathology and recovery processes during the chronic phases of stroke. The study suggests a potential immune-based strategy to modify injury progression and tissue remodeling in ischemic stroke.


Conditions & Recovery

Stroke icon
Stroke is the leading cause of disability in the U.S.
Cognitive Recovery icon
Remember and speak clearly.

Research Methods