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Sensory circuit remodeling and movement recovery after SCI

Yunuen Moreno-López, Edmund R. Hollis
Year Published: 
Front Neurosci. 2021 Dec 8;15:787690. doi: 10.3389/fnins.2021.787690. eCollection 2021.
Full-Text on PMC


Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.


Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.
Motor Recovery Icon
Write and walk again.
Pain and Sensory Recovery Icon
Pain free, touch and smell like before.