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Rod-mediated Dark Adaptation as a Functional Biomarker for Early AMD

Who Should Attend: 
Event Flyer: 
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Nathan E. Miles Endowed Chair of Ophthalmology Director, Clinical Research Unit/Department of Ophthalmology and Visual Sciences


Approved strategies for reducing the burden of age-related macular degeneration (AMD) focus on preventing or stabilizing neovascularization and slowing the progression of preexisting atrophy. Yet, the vast majority of people with AMD have earlier disease. I will describe my research over the past 20 years addressing a psychophysical test, rod-mediated dark adaptation, that is linked to early and intermediate AMD, which potentially could be used as a functional endpoint in trials focused on early disease. I will also describe how rod-mediated dark adaptation is linked to structural characteristics of AMD in its earlier phases


Owsley C, Swain TA, Kar D, Curcio CA.
Rod mediated dark adaptation, a functional test for early and intermediate AMD outcomes.
Expert Review of Ophthalmology, 2024; 19(1): 1-5.
Owsley C, Swain TA, McGwin G Jr, Clark ME, Kar D, Crosson JN, Curcio CA.
How vision is impaired from aging to early and intermediate age-related macular degeneration: Insights from ALSTAR2 baseline.
Translational Vision and Technology 2022;11: 17.
Owsley C, Swain TA, McGwin G Jr, Clark ME, Kar D, Curcio CA.
Biologically guided optimization of test target location for rod-mediated dark adaptation in age-related macular degeneration: ALSTAR2.
Ophthalmology Science 2022; 3: 100274.


Tuesday, March 26, 2024 - 12:30pm


Conference Room: 
Billings Building – Rosedale

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