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Proteostasis and Inflammation: New Insights and Therapeutic Strategies in Neurodegeneration

Weekly Seminar | Not Open to the Public
Who Should Attend: 


The fast progress in human genetics reveals common molecular mechanisms in aging-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). I will focus the discussion on two converging pathways linking AD and FTD, including innate immunity and proteostasis. In human iPSC and mouse models of disease, our research employs a combination of in vitro and in vivo approaches, such as genomic and proteomic approaches, electrophysiology, and behavioral tests. I will discuss our recent work on identification of key pathways in microglia-mediated neuronal injury and novel mechanisms regulating homeostasis of tau, a key pathogen in AD and FTD. I will also discuss how dysregulated innate immune response contributes to proteostasis malfunction.

Li Gan's Figure Photo


Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho SH, Sayed F, Li Y, Le D Zhou Y, Shen Y, West B6, Gan L.
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
PLoS Biol. 2019 Feb 8;17(2):e3000134. doi: 10.1371/journal.pbio.3000134. eCollection 2019 Feb.
Gan L, Cookson MR, Petrucelli L, La Spada AR.
Converging pathways in neurodegeneration, from genetics to mechanisms.
Nat Neurosci. 2018 Oct;21(10):1300-1309. doi: 10.1038/s41593-018-0237-7. Epub 2018 Sep 26.
Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10172-10177. doi: 10.1073/pnas.1811411115. Epub 2018 Sep 19.


Tuesday, June 4, 2019 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Conditions & Recovery

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Worldwide, 50 million people are living with Alzheimer's and other dementias.
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Remember and speak clearly.