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Neuronal Intrinsic Inhibitors Regulating Axon Regeneration

Weekly Seminar | Not Open to the Public
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The failure of axon regeneration in the adult mammalian central nervous system (CNS) attributed to two properties of the adult CNS, the inhibitory extrinsic environment and a diminished intrinsic regenerative capacity of mature CNS neurons. Successful regeneration through modulating neuronal intrinsic mechanisms in CNS neurons requires activation of proregenerative transcription and translation, epigenetic regulation, cytoskeletal dynamics and transport, mitochondrial mobility, among other processes. Our recent study reveals a critical role of phosphatidate phosphatase lipin1 and diglyceride acyltransferases (DGATs) as intrinsic regulators of glycerolipid metabolism in neurons. In both the optic nerve and spinal cord injury models, we found that inhibiting these enzymes can promote axon regrowth. We propose another strategy for neural repair by directing neuronal lipid synthesis away from triglyceride synthesis and toward phospholipid synthesis.

Dr. Kai Liu's Figure


Chao Yang , Xu Wang, Jianying Wang, Xuejie Wang, Weitao Chen, Na Lu, Symeon Siniossoglou, Zhongping Yao, Kai Liu
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
Neuron. 2020 Jan 22;105(2):276-292.e5. doi: 10.1016/j.neuron.2019.10.009. Epub 2019 Nov 27.
Songshan Li, Chao Yang, Li Zhang, Xin Gao, Xuejie Wang, Wen Liu, Yuqi Wang, Songshan Jiang, Yung Hou Wong, Yifeng Zhang, Kai Liu
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1937-42. doi: 10.1073/pnas.1523645113. Epub 2016 Feb 1.
Kaimeng Du, Susu Zheng, Qian Zhang, Songshan Li, Xin Gao, Juan Wang, Liwen Jiang, Kai Liu
Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury
J Neurosci. 2015 Jul 1;35(26):9754-63. doi: 10.1523/JNEUROSCI.3637-14.2015.


Tuesday, September 7, 2021 - 12:30pm


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Darlene White

Conditions & Recovery

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