Molecular Mechanisms of Spontaneous CNS Axon Regeneration.

Abstract

In contrast to most mammals, zebrafish have retained a remarkable capacity for spontaneous CNS regeneration. combined with its optical transparency This provides an unique opportunity to complement studies in mammalian systems that focus on overcoming inhibitory mechanisms with studies to identify mechanisms that promote regrowth of injured CNS axons without the confounds of inhibitory mechanisms. I will discuss progress on neuron intrinsic and extrinsic ie glia derived signals that promote axon regeneration in the vertebrate CNS.