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Intermittent Hypoxia and Spinal Motor Plasticity: Breathing and Walking after Spinal Cord Injury

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Speakers

Dr. Gordon Mitchell's Photo
Preeminence Professor of Neuroscience and Physical Therapy

Abstract

After decades of fundamental research investigating mechanisms giving rise to spinal motor plasticity following exposure to (low dose) acute intermittent hypoxia, we harnessed this plasticity to improve breathing and limb function in people with chronic incomplete spinal cord injury (as well as ALS). In this talk, I will review fundamental research guiding translation of this novel neurotherapeutic strategy, and then feature more recent efforts to optimize plasticity and functional gains by recognizing and controlling factors that constrain plasticity and therapeutic efficacy.

Dr. Gordon Mitchell's Figure

Publications

Elisa J Gonzalez-Rothi, Kun-Ze Lee, Erica A Dale, Paul J Reier, Gordon S Mitchell, David D Fuller
Intermittent hypoxia and neurorehabilitation
J Appl Physiol (1985). 2015 Dec 15;119(12):1455-65. doi: 10.1152/japplphysiol.00235.2015. Epub 2015 May 21.
Arash Tadjalli, Yasin B Seven, Raphael R Perim, Gordon S Mitchell
Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity
J Neuroinflammation. 2021 Jan 19;18(1):28. doi: 10.1186/s12974-021-02074-6.
Raphael R Perim, Elisa J Gonzalez-Rothi, Gordon S Mitchell
Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation
Exp Neurol. 2021 Apr 26;113726. doi: 10.1016/j.expneurol.2021.113726. Online ahead of print.

When

Tuesday, May 18, 2021 - 12:30pm

Where

Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.