Disinhibition in the nervous system

Clinical practice

Dr. Pascual consults on pediatric and adult inpatients and outpatients with particularly complex or severe diseases or with multi-organ disorders. He specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with an emphasis on diagnostic problems, second opinions for patients visiting from across the U.S. and abroad, and on clinical trials.

Research

As one of few actively practicing pediatric neurologists in the nation who is also a laboratory scientist, his research interests span virtually the entire field of neuroscience, from molecular structure and function (including drug action), neural physiology and metabolism at the cellular, circuit and whole-brain level and neurogenetics. His research has been continuously funded by the National Institutes of Health.

Outreach and leadership

Dr. Pascual has co-authored dozens of scientific, medical and philosophical textbooks and over 100 scientific articles. He is an acclaimed team builder and leads, together with Dr. Roger Rosenberg, a team of 200 international authors responsible for the hallmark textbook Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (5th to current 7th edition). His textbook Progressive Brain Disorders in Childhood appeared in 2017. He is working on a new book, provisionally entitled Sense & Nonsense in Medical Neuroscience, to be published by Cambridge University Press. He is a lead principal investigator in the first Team Science initiative funded by the National Institute of Neurological Disorders and Stroke and is expert in clinical program development and institutional transformation. His laboratory is home to scientists and trainees with very diverse expertise, who collaborate with researchers and clinicians located worldwide. At UT Southwestern, he founded a patient-awarded medical program that leveraged an unprecedented number of experts and newly-developed technology in a seamless manner to diagnose and treat patients who had exhausted all other approaches.

More information

Recent clinical research studies 

Recent NIH-funded research projects 

Journal publications (PubMed)