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CSF Soluble p-tau Identify Stages of Tauopathy in Dominantly Inherited AD

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Eric McDade's Photo
Associate Director
Dominantly Inherited Alzheimer Network Trials Unit


Eric McDade, DO, is an Associate Professor of Neurology at the Washington University School of Medicine in St. Louis. His research interests include the application of cerebrospinal fluid and neuroimaging measures to identify early pathology of Alzheimer’s disease, the interaction of cerebrovascular function and Alzheimer pathology with the ultimate goal of identifying early markers of Alzheimer’s disease progression that can be used in testing disease modifying therapies.

Dr. McDade serves as the Associate Director of the Dominantly Inherited Alzheimer’s Disease Trials Unit and the Clinical Core Leader of the Dominantly Inherited Alzheimer Network Observational Study where he and his colleagues are using a global, natural history study to develop prevention trials to in Dominantly Inherited AD. As part of this work he is the Principle Investigator of the first ever primary prevention trial in familial Alzheimer disease which will test whether preventing the development of amyloid plaques will prevent the development of dementia in those with a genetic form of the Alzheimer’s disease that leads to young-onset dementia.

Dr. Eric McDade's Figure


Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Sarah B Berman, Takeshi Ikeuchi, Hiroshi Mori, Hiroyuki Shimada, Mikio Shoji, Kazushi Suzuki, James Noble, Martin Farlow, Jasmeer Chhatwal, Neill R Graff-Radford, Stephen Salloway, Peter R Schofield, Colin L Masters, Ralph N Martins, Antoinette O'Connor, Nick C Fox, Johannes Levin, Mathias Jucker, Audrey Gabelle, Sylvain Lehmann, Chihiro Sato, Randall J Bateman, Eric McDade, Dominantly Inherited Alzheimer Network
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease
Nat Med. 2020 Mar;26(3):398-407. doi: 10.1038/s41591-020-0781-z. Epub 2020 Mar 11.
Jorge J Llibre-Guerra, Yan Li, Suzanne E Schindler, Brian A Gordon, Anne M Fagan, John C Morris, Tammie L S Benzinger, Jason Hassenstab, Guoqiao Wang, Ricardo Allegri, Sarah B Berman, Jasmeer Chhatwal, Martin R Farlow, David M Holtzman, Mathias Jucker, Johannes Levin, James M Noble, Stephen Salloway, Peter Schofield, Celeste Karch, Nick C Fox, Chengjie Xiong, Randall J Bateman, Eric McDade
Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease
JAMA Netw Open. 2019 Dec 2;2(12):e1917126. doi: 10.1001/jamanetworkopen.2019.17126.
Eric McDade, Guoqiao Wang, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, David M Holtzman, Nigel J Cairns, Alison M Goate, Daniel S Marcus, John C Morris, Katrina Paumier, Chengjie Xiong, Ricardo Allegri, Sarah B Berman, William Klunk, James Noble, John Ringman, Bernardino Ghetti, Martin Farlow, Reisa A Sperling, Jasmeer Chhatwal, Stephen Salloway, Neill R Graff-Radford, Peter R Schofield, Colin Masters, Martin N Rossor, Nick C Fox, Johannes Levin, Mathias Jucker, Randall J Bateman, Dominantly Inherited Alzheimer Network
Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease
Neurology. 2018 Oct 2;91(14):e1295-e1306. doi: 10.1212/WNL.0000000000006277. Epub 2018 Sep 14.


Tuesday, February 2, 2021 - 12:30pm


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Darlene White

Conditions & Recovery

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