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Brainstem Circuits that Control the Episodic, Context-dependent Expression and Directionality of Locomotion

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Abstract

The capacity for movement is essential to life. Of movements, locomotion is one of the most fundamental and the output measure of many complex brain functions. To be executed, locomotion requires dynamic initiation and termination and appropriate directionally. This lecture will focus on recent advances that has elucidated the functional organization of brainstem motor circuits in mammals needed to perform these roles. It will show that designated command pathways in the brainstem control the episodic and context-dependent expression of locomotion and that directionality of locomotion is controlled by asymmetric activity in discrete brainstem circuits. The work suggest specific links to how higher brain functions are executed through movement acts and how locomotor disturbances following basal ganglia disorders may be alleviated.

Dr. Oli Kiehn's Figure

Publications

Julien Bouvier, Vittorio Caggiano, Roberto Leiras, Vanessa Caldeira, Carmelo Bellardita, Kira Balueva, Andrea Fuchs, Ole Kiehn
Descending Command Neurons in the Brainstem that Halt Locomotion
Cell. 2015 Nov 19;163(5):1191-1203. doi: 10.1016/j.cell.2015.10.074.
V Caggiano, R Leiras, H Goñi-Erro, D Masini, C Bellardita, J Bouvier, V Caldeira, G Fisone, O Kiehn
Midbrain circuits that set locomotor speed and gait selection
Nature. 2018 Jan 25;553(7689):455-460. doi: 10.1038/nature25448. Epub 2018 Jan 17.
Jared M Cregg, Roberto Leiras, Alexia Montalant, Paulina Wanken, Ian R Wickersham, Ole Kiehn
Brainstem neurons that command mammalian locomotor asymmetries
Nat Neurosci. 2020 Jun;23(6):730-740. doi: 10.1038/s41593-020-0633-7. Epub 2020 May 11.

When

Tuesday, April 20, 2021 - 12:30pm

Where

Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

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