Histone deacetylases inhibitors for neurotherapeutics

Histone deaceytlase (HDAC) inhibitors are a promising therapeutic of neurological diseases. The research focuses on using HDAC inhibitors to block neurodegeneration and promote neurorepair. The acetylation of histone proteins increases gene expression, and by blocking the removal of acetyl groups, HDAC inhibitors elevate histone acetylation. As a result of HDAC inhibition, a large transcriptional response occurs, which appears to enhance neuronal survival. Researchers are interested in identifying which of the 11 Zn-dependent HDACs are most critical in order to promote the ideal gene expression profile for neuronal survival. Additionally, the effects of diet on the production of endogenous HDAC inhibitors is also being investigated specifically on how dietary interventions can be used to treat neurological diseases, including Alzheimer’s disease and stroke.