Oxidative Stress

Impact

NEWS:

Article

June 4, 2021

Decades of Research Advancements Pave the Way to Slow Down Alzheimer’s Disease by Targeting Early-Onset

Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.

Ratan Lab

PUBLICATION:

Journal Article

George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres , Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

PLoS One. 2021 Apr 5;16(4):e0249591. doi: 10.1371/journal.pone.0249591. eCollection 2021.

Full-Text on Pubmed

Gibson Lab

NEWS:

In the Media

December 29, 2020

Benfotiamine and Cognitive Decline in Alzheimer's Disease Study Listed as a Top Non-Pandemic Advances in Health Care During 2020

Media Outlet:

CNN Health

Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.

Gibson Lab

NEWS:

Article

November 25, 2020

New Data Suggests Raising Vitamin B1 Levels very high Helps People Living with mild Alzheimer’s Disease

A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).

Gibson Lab

PUBLICATION:

Manuscript

Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial

J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.

Full-Text on Pubmed

Gibson Lab

PUBLICATION:

Journal Article

Michael Wagner, Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Gary E Gibson, Ward Heggermont, Stephane Heymans, Christoph Maack

Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart

Basic Res Cardiol . 2020 Aug 3;115(5):53. doi: 10.1007/s00395-020-0815-1.

Full-Text on Pubmed

PUBLICATION:

Journal Article

Devrim Sarıbal, Aslı Kireçtepe Aydın, Mahmut Alp Kılıç, Faariah Shakil, Mustafa Balkaya

Maternal Neglect Results in Reduced Telomerase Activity and Increased Oxidative Load in Rats

Stress. 2021 May;24(3):348-352. doi: 10.1080/10253890.2020.1777973. Epub 2020 Jun 26.

Abstract on PubMed

Ratan Lab

NEWS:

Article

May 22, 2020

Cell Chemical Biology Features Review Article on Ferroptosis in the Central Nervous System by Dr. Raj Ratan

May 6, 2020 – Featured on the cover of Cell Chemical Biology, a new and significant review article by Dr. Raj Ratan, Executive Director of the Burke Neurological Institute, examines “The Chemical Biology of Ferroptosis in the Central Nervous System.”