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Oxidative Stress

Impact

NEWS: 
Article
Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.
Gibson Team in the Lab
PUBLICATION: 
Journal Article
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres , Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
PLoS One. 2021 Apr 5;16(4):e0249591. doi: 10.1371/journal.pone.0249591. eCollection 2021.
Full-Text on Pubmed
NEWS: 
In the Media
Media Outlet: 
CNN Health
Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.
Gibson Team in the Lab
NEWS: 
Article
A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).
Photo of Gibson Lab
PUBLICATION: 
Manuscript
Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti
J Alzheimers Dis . 2020 Oct 16. doi: 10.3233/JAD-200896. Online ahead of print.
Abstract on PubMed
PUBLICATION: 
Journal Article
Michael Wagner, Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Gary E Gibson, Ward Heggermont, Stephane Heymans, Christoph Maack
Basic Res Cardiol . 2020 Aug 3;115(5):53. doi: 10.1007/s00395-020-0815-1.
Full-Text on Pubmed
PUBLICATION: 
Journal Article
Devrim Sarıbal, Aslı Kireçtepe Aydın, Mahmut Alp Kılıç, Faariah Shakil, Mustafa Balkaya
Stress. 2021 May;24(3):348-352. doi: 10.1080/10253890.2020.1777973. Epub 2020 Jun 26.
Abstract on PubMed
NEWS: 
Article
May 6, 2020 – Featured on the cover of Cell Chemical Biology, a new and significant review article by Dr. Raj Ratan, Executive Director of the Burke Neurological Institute, examines “The Chemical Biology of Ferroptosis in the Central Nervous System.”
Cell Chemical Biology Cover May 2020
PUBLICATION: 
Review
Rajiv R. Ratan
Cell Chem Biol. 2020 Mar 24. pii: S2451-9456(20)30081-7. doi: 10.1016/j.chembiol.2020.03.007. [Epub ahead of print]
Full-Text on Cell Chemical Biology
GRANT: 
Federal
February 1, 2019 to January 31, 2024
Funding Status: 
Active Project
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Grant Number: 
R01NS111943
Investigators: 
Principal Investigator
Co-Investigator