Publications for Gary E. Gibson, Ph.D. | Burke Neurological Institute

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Publications for Gary E. Gibson, Ph.D.

Showing 1 - 269 of 269 total

PUBLICATION:

Review

Hussein N. Yassine,Wade Self,Bilal E. Kerman,Giulia Santoni,NandaKumar Navalpur Shanmugam,Laila Abdullah,Lesley R. Golden,Alfred N. Fonteh,Michael G. Harrington,Johannes Gräff,Gary E. Gibson,Raj Kalaria,Jose A. Luchsinger,Howard H. Feldman,Russell H. Swerdlow,Lance A. Johnson,Benedict C. Albensi,Berislav V. Zlokovic,Rudolph Tanzi,Stephen Cunnane,Cécilia Samieri,Nikolaos Scarmeas,Gene L. Bowman,Nutrition, Metabolism and Dementia PIA, Alzheimer's Association ISTAART

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Alzheimers Dement. 2022 Dec 8. doi: 10.1002/alz.12845. Online ahead of print.

Full Text on Wiley

PUBLICATION:

Review

Grace E Hansen, Gary E Gibson

The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration

Int J Mol Sci. 2022 Oct 17;23(20):12403. doi: 10.3390/ijms232012403.

Full-Text on PMC

PUBLICATION:

Opinion Article

Gary E Gibson, Howard H Feldman, Sheng Zhang, Sarah A Flowers, José A Luchsinger

Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease

Front Med (Lausanne). 2022 Oct 4;9:1033272. doi: 10.3389/fmed.2022.1033272. eCollection 2022.

Full-Text on Frontiers

PUBLICATION:

Journal Article

Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang & Gary E. Gibson

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Nat Commun. 2022 Jan 10;13(1):159. doi: 10.1038/s41467-021-27572-2.

Open Access on Nature

PUBLICATION:

Journal Article

Ruchika Bhawal, Qin Fu, Elizabeth T. Anderson, Gary E. Gibson, and Sheng Zhang

Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer’s Disease

Int J Mol Sci. 2021 Dec 7;22(24):13188. doi: 10.3390/ijms222413188.

Full-Text on MDPI

PUBLICATION:

Letter

Victor Tapias, Gary E Gibson, Costantino Iadecola

Obituary: In Memory of Myron Flint Beal, MD, November 6, 1950-June 12, 2021

Mov Disord. 2021 Sep;36(9):2003-2004. doi: 10.1002/mds.28743. Epub 2021 Aug 7.

PUBLICATION:

Journal Article

Lidan Sun, Ruchika Bhawal, Hui Xu, Huanlian Chen, Elizabeth T Anderson, Vahrum Haroutunian, Abigail C Cross, Sheng Zhang, Gary E Gibson

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease

J Neurochem. 2021 Jul;158(2):282-296. doi: 10.1111/jnc.15377. Epub 2021 May 12.

Abstract on PubMed

PUBLICATION:

Review

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, ...

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8.

Abstract on PubMed

PUBLICATION:

Manuscript

Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial

J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.

Full-Text on Pubmed

PUBLICATION:

Journal Article

Huanlian Chen, Abigail C Cross, Ankita Thakkar, Hui Xu, Aiqun Li, Dan Paull, Scott A Noggle, Laken Kruger, Travis T Denton, Gary E Gibson

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

J Neurochem. 2021 Mar;156(6):867-879. doi: 10.1111/jnc.15160. Epub 2020 Sep 12.

Abstract on PubMed

PUBLICATION:

Journal Article

Michael Wagner, Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Gary E Gibson, Ward Heggermont, Stephane Heymans, Christoph Maack

Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart

Basic Res Cardiol . 2020 Aug 3;115(5):53. doi: 10.1007/s00395-020-0815-1.

Full-Text on Pubmed

PUBLICATION:

Review

Yang Y, Gibson GE.

Succinylation Links Metabolism to Protein Functions.

Neurochem Res. 2019 Oct;44(10):2346-2359. doi: 10.1007/s11064-019-02780-x. Epub 2019 Mar 22.

Abstract on PubMed

PUBLICATION:

Journal Article

Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, Wakade S, Calingasan NY, Thomas B, Gibson GE, Dumont M, Beal MF.

Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy.

Hum Mol Genet. 2018 Aug 15;27(16):2874-2892. doi: 10.1093/hmg/ddy201.

Abstract on PubMed

PUBLICATION:

Journal Article

Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE.

Mild metabolic perturbations alter succinylation of mitochondrial proteins.

J Neurosci Res. 2017 Jun 20. doi: 10.1002/jnr.24103. [Epub ahead of print]

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Thakkar A.

Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility.

Neurochem Int. 2017 Jun 13. pii: S0197-0186(17)30332-7. doi: 10.1016/j.neuint.2017.06.007. [Epub ahead of print]

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Thakkar A.

Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.

Neurochem Res. 2017 Jun;42(6):1636-1648. doi: 10.1007/s11064-017-2182-3. Epub 2017 Feb 8.

Abstract on PubMed

PUBLICATION:

Journal Article

Naseri NN, Bonica J, Xu H, Park LC, Arjomand J, Chen Z, Gibson GE.

Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients.

PLoS One. 2016 Sep 9;11(9):e0160384. doi: 10.1371/journal.pone.0160384.

Full-Text on PubMed

PUBLICATION:

Journal Article

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J.

Vitamin B1 (thiamine) and dementia.

Ann N Y Acad Sci. 2016 Mar;1367(1):21-30. doi: 10.1111/nyas.13031. Epub 2016 Mar 11.

Abstract on PubMed

Cho Lab / Gibson Lab

PUBLICATION:

Journal Article

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE.

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.

Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23.

Abstract on PubMed

PUBLICATION:

Review

Banerjee K, Munshi S, Frank DE, Gibson GE.

Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches.

Neurochem Res. 2015 Dec;40(12):2557-69. doi: 10.1007/s11064-015-1631-0. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE.

Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.

J Neuropathol Exp Neurol. 2015 Jun;74(6):527-37. doi: 10.1097/NEN.0000000000000197.

Full-Text on PubMed

PUBLICATION:

Journal Article

Zhao W, Wang J, Varghese M, Ho L, Mazzola P, Haroutunian V, Katsel PL, Gibson GE, Levine S, Dubner L, Pasinetti GM.

Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects.

Neuropsychiatr Dis Treat. 2015 Mar 5;11:565-74. doi: 10.2147/NDT.S74898.

Full-Text on PubMed

PUBLICATION:

Journal Article

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S.

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096.

Full Text on PubMed

PUBLICATION:

Journal Article

Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M.

The RNA-binding protein HuR is essential for the B cell antibody response.

Nat Immunol. 2015 Apr;16(4):415-25. doi: 10.1038/ni.3115.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Gibson GE.

Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry.

Metab Brain Dis. 2014 Dec;29(4):1083-93. doi: 10.1007/s11011-014-9541-4.

Full-Text on PubMed

PUBLICATION:

Journal Article

Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C.

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.

FASEB J. 2013 Jun;27(6):2392-406. doi: 10.1096/fj.12-220202.

Full-Text on PubMed

PUBLICATION:

Review

Gibson GE, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J.

Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes.

Mol Cell Neurosci. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Review.

Full-Text on PubMed

PUBLICATION:

Journal Article

Gibson GE, Starkov A, Shi Q, Beal MF.

α-Ketoglutarate Dehydrogenase Complex in Neurodegeneration

Mitochondria and Cell Signaling in Health and Disease. Volume 27. Oxidative Stress and Disease. 2012 July; 27.

PUBLICATION:

Book Chapter

Gibson GE, Starkov A, Shi Q, Beal MF.

Mitochondrial Signaling in Health and Disease: Alpha-ketoglutarate Dehydrogenase Complex in Neurodegeneration

Orrenius S, Packer P, Enrique C, editors. Baca Raton London New York: CRC Press; 2012. Chapter 19, Alpha-ketoglutarate Dehydrogenase Complex in Neurodegeneration; p.433-454. 500p.

Book on CRC Press

PUBLICATION:

Journal Article

Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q.

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.

Neurobiol Aging. 2012 Jun;33(6):1121.e13-24. doi: 10.1016/j.neurobiolaging.2011.11.003.

Full-Text on PubMed

PUBLICATION:

Journal Article

Shi Q, Gibson GE.

Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a.

J Neurochem. 2011 Aug;118(3):440-8. doi: 10.1111/j.1471-4159.2011.07333.x.

Full-Text on PubMed

PUBLICATION:

Journal Article

Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, Gibson GE.

Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.

J Biol Chem. 2011 May 20;286(20):17640-8. doi: 10.1074/jbc.M110.203018.

Full-Text on PubMed

PUBLICATION:

Journal Article

Nilsen LH, Shi Q, Gibson GE, Sonnewald U.

Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.

J Neurosci Res. 2011 Dec;89(12):1997-2007. doi: 10.1002/jnr.22606.

Full-Text on PubMed

PUBLICATION:

Journal Article

Bubber P, Hartounian V, Gibson GE, Blass JP.

Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients.

Eur Neuropsychopharmacol. 2011 Mar;21(3):254-60. doi: 10.1016/j.euroneuro.2010.10.007.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Gibson GE.

Thiamine and oxidants interact to modify cellular calcium stores.

Neurochem Res. 2010 Dec;35(12):2107-16. doi: 10.1007/s11064-010-0242-z.

Full-Text on PubMed

PUBLICATION:

Review

Gibson GE, Shi Q.

A mitocentric view of Alzheimer's disease suggests multi-faceted treatments.

J Alzheimers Dis. 2010;20 Suppl 2:S591-607. doi: 10.3233/JAD-2010-100336. Review.

Full-Text on PubMed

PUBLICATION:

Journal Article

Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA.

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

Am J Pathol. 2009 Nov;175(5):1810-6. doi: 10.2353/ajpath.2009.090219.

Full-Text on PubMed

Gibson Lab / Ratan Lab

PUBLICATION:

Review

Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF.

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Biochim Biophys Acta. 2010 Jan;1802(1):122-34. doi: 10.1016/j.bbadis.2009.08.010. Review.

Full-Text on PubMed

PUBLICATION:

Journal Article

Yang L, Shi Q, Ho DJ, Starkov AA, Wille EJ, Xu H, Chen HL, Zhang S, Stack CM, Calingasan NY, Gibson GE, Beal MF.

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.

Neurobiol Dis. 2009 Nov;36(2):320-30. doi: 10.1016/j.nbd.2009.07.023.

Full-Text on PubMed

PUBLICATION:

Journal Article

Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson G, Beal MF.

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.

Free Radic Biol Med. 2009 Oct 1;47(7):1019-27. doi: 10.1016/j.freeradbiomed.2009.07.008.

Full-Text on PubMed

PUBLICATION:

Journal Article

Shi Q, Risa Ø, Sonnewald U, Gibson GE.

Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis.

J Neurochem. 2009 May;109 Suppl 1:214-21. doi: 10.1111/j.1471-4159.2009.05955.x.

Full-Text on PubMed

Gibson Lab / Ratan Lab

PUBLICATION:

Journal Article

Gibson GE, Ratan RR, Beal MF.

Mitochondria and oxidative stress in neurodegenerative disorders. Preface.

Ann N Y Acad Sci. 2008 Dec;1147:xi-xii. doi: 10.1196/annals.1427.039. No abstract available.

PUBLICATION:

Review

Gibson GE, Karuppagounder SS, Shi Q.

Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease.

Ann N Y Acad Sci. 2008 Dec;1147:221-32. doi: 10.1196/annals.1427.038. Review.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE.

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Neurochem Int. 2009 Feb;54(2):111-8. doi: 10.1016/j.neuint.2008.10.008.

Full-Text on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Ho DJ, Wille EJ, Campagna MV, Ruan J, Dumont M, Yang L, Shi Q, Gibson GE, Beal MF.

Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.

Neuroscience. 2008 Jun 2;153(4):986-96. doi: 10.1016/j.neuroscience.2008.02.071.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE.

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

Neurobiol Aging. 2009 Oct;30(10):1587-600. doi: 10.1016/j.neurobiolaging.2007.12.013.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Xu H, Pechman D, Chen LH, DeGiorgio LA, Gibson GE.

Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism.

Neurochem Res. 2008 Jul;33(7):1365-72. doi: 10.1007/s11064-008-9594-z.

Full-Text on PubMed

PUBLICATION:

Journal Article

Shi Q, Xu H, Kleinman WA, Gibson GE.

Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.

Biochim Biophys Acta. 2008 Apr;1782(4):229-38. doi: 10.1016/j.bbadis.2007.12.008.

Full-Text on PubMed

PUBLICATION:

Book Chapter

Karuppagounder SS, Gibson GE.

Metabolic Encephalopathy; Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability

McCandless DW, editor. New York: Springer; 2008. Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability; p.235-260.

Book on Springer

PUBLICATION:

Review

Shi Q, Gibson GE.

Oxidative stress and transcriptional regulation in Alzheimer disease.

Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):276-91. Review.

Full-Text on PubMed

PUBLICATION:

Review

Gibson GE, Blass JP.

Thiamine-dependent processes and treatment strategies in neurodegeneration.

Antioxid Redox Signal. 2007 Oct;9(10):1605-19. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Shi Q, Karuppagounder SS, Xu H, Pechman D, Chen H, Gibson GE.

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.

Neurochem Int. 2007 Jun;50(7-8):921-31.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Shi Q, Xu H, Gibson GE.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.

Neurobiol Dis. 2007 May;26(2):353-62.

Full-Text on PubMed

PUBLICATION:

Review

Bunik VI, Schloss JV, Pinto JT, Gibson GE, Cooper AJ.

Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases.

Neurochem Res. 2007 Apr-May;32(4-5):871-91. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE.

Neurochem Res. 2007 Apr-May;32(4-5):533-4. No abstract available.

PUBLICATION:

Book Chapter

Joseph JA, Gibson GE.

Handbook of Neurochemistry and Molecular Biology. 3rd Edition Volume 5. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia.

Gibson GE, Dienel G, editors. New York: Springer; 2007. Chapter 4.2, Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia.; p.297-320.

Book on Springer

PUBLICATION:

Journal Article

Blass JP, Gibson GE.

Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans.

J Alzheimers Dis. 2006 Jul;9(2):207-18.

Abstract on PubMed

PUBLICATION:

Journal Article

Zhang L, Cooper AJ, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH.

Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.

Biochemistry. 2006 Jul 25;45(29):8959-71.

Full-Text on PubMed

PUBLICATION:

Journal Article

Ke ZJ, Bowen WM, Gibson GE.

Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism.

Neurochem Int. 2006 Oct;49(5):548-56.

Abstract on PubMed

PUBLICATION:

Journal Article

Murphy EJ, Huang HM, Cowburn RF, Lannfelt L, Gibson GE.

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.

Brain Res Bull. 2006 Mar 15;69(1):79-85.

Abstract on PubMed

PUBLICATION:

Journal Article

Santos SS, Gibson GE, Cooper AJ, Denton TT, Thompson CM, Bunik VI, Alves PM, Sonnewald U.

Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons.

J Neurosci Res. 2006 Feb 15;83(3):450-8.

Abstract on PubMed

PUBLICATION:

Journal Article

Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE, Cooper AJ.

Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.

Neurochem Res. 2005 Oct;30(10):1245-55.

Abstract on PubMed

PUBLICATION:

Journal Article

Waagepetersen HS, Hansen GH, Fenger K, Lindsay JG, Gibson G, Schousboe A.

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase.

Glia. 2006 Jan 15;53(2):225-31.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Xu H, Gibson GE.

Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease.

Free Radic Biol Med. 2005 Oct 15;39(8):979-89.

Abstract on PubMed

PUBLICATION:

Journal Article

Bunik VI, Denton TT, Xu H, Thompson CM, Cooper AJ, Gibson GE.

Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.

Biochemistry. 2005 Aug 9;44(31):10552-61.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Blass JP, Beal MF, Bunik V.

The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.

Mol Neurobiol. 2005;31(1-3):43-63. Review.

Abstract on PubMed

Ratan Lab / Gibson Lab

PUBLICATION:

Journal Article

Krasnikov BF, Kim SY, McConoughey SJ, Ryu H, Xu H, Stavrovskaya I, Iismaa SE, Mearns BM, Ratan RR, Blass JP, Gibson GE, Cooper AJ.

Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.

Biochemistry. 2005 May 31;44(21):7830-43.

Full-Text on PubMed

PUBLICATION:

Journal Article

Ke ZJ, Calingasan NY, Karuppagounder SS, DeGiorgio LA, Volpe BT, Gibson GE.

CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism.

J Neuroimmunol. 2005 Jul;164(1-2):85-92.

Abstract on PubMed

PUBLICATION:

Journal Article

Ke ZJ, Calingasan NY, DeGiorgio LA, Volpe BT, Gibson GE.

CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism.

Neurochem Int. 2005 Aug;47(3):204-15.

Abstract on PubMed

PUBLICATION:

Journal Article

Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE.

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications.

Ann Neurol. 2005 May;57(5):695-703.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Fowler C, Xu H, Zhang H, Gibson GE.

Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease.

Neurobiol Aging. 2005 Jun;26(6):839-48.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Huang HM.

Oxidative stress in Alzheimer's disease.

Neurobiol Aging. 2005 May;26(5):575-8. Review. No abstract available.

PUBLICATION:

Journal Article

Shi Q, Chen HL, Xu H, Gibson GE.

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

J Biol Chem. 2005 Mar 25;280(12):10888-96.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Zhang H, Ou HC, Chen HL, Gibson GE.

Alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores.

Free Radic Biol Med. 2004 Dec 1;37(11):1779-89.

Abstract on PubMed

PUBLICATION:

Journal Article

Bubber P, Tang J, Haroutunian V, Xu H, Davis KL, Blass JP, Gibson GE.

Mitochondrial enzymes in schizophrenia.

J Mol Neurosci. 2004;24(2):315-21.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Huang HM.

Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases.

J Bioenerg Biomembr. 2004 Aug;36(4):335-40. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Bubber P, Ke ZJ, Gibson GE.

Tricarboxylic acid cycle enzymes following thiamine deficiency.

Neurochem Int. 2004 Dec;45(7):1021-8.

Abstract on PubMed

PUBLICATION:

Review

Ke ZJ, Gibson GE.

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism.

Neurochem Int. 2004 Jul-Aug;45(2-3):361-9. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Fowler C, Zhang H, Gibson GE.

Mitochondrial heterogeneity within and between different cell types.

Neurochem Res. 2004 Mar;29(3):651-8.

Abstract on PubMed

PUBLICATION:

Journal Article

Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson GE, Patel MS, Beal MF.

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.

J Neurochem. 2004 Mar;88(6):1352-60.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE.

Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

J Neurosci Res. 2003 Oct 15;74(2):309-17.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Kingsbury AE, Xu H, Lindsay JG, Daniel S, Foster OJ, Lees AJ, Blass JP.

Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease.

Neurochem Int. 2003 Jul;43(2):129-35.

Abstract on PubMed

PUBLICATION:

Journal Article

Ke ZJ, DeGiorgio LA, Volpe BT, Gibson GE.

Reversal of thiamine deficiency-induced neurodegeneration.

J Neuropathol Exp Neurol. 2003 Feb;62(2):195-207.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Zhang H, Xu H, Gibson GE.

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.

Biochim Biophys Acta. 2003 Jan 20;1637(1):119-26.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Gibson GE, Hoyer S.

The role of the metabolic lesion in Alzheimer's disease.

J Alzheimers Dis. 2002 Jun;4(3):225-32. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Zhang H.

Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease.

J Alzheimers Dis. 2001 Jun;3(3):329-338.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE.

Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease.

Free Radic Biol Med. 2002 Jun 1;32(11):1061-70. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Zhang H, Xu H, Park LC, Jeitner TM.

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme.

Biochim Biophys Acta. 2002 Mar 16;1586(2):177-89.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Huang HM.

Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease.

Front Biosci. 2002 Apr 1;7:d1007-15. Review.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Zhang H.

Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration.

Neurochem Int. 2002 May;40(6):493-504. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Zhang H, Huang HM, Carson RC, Mahmood J, Thomas HM, Gibson GE.

Assessment of membrane potentials of mitochondrial populations in living cells.

Anal Biochem. 2001 Nov 15;298(2):170-80.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Albers DS, Xu H, Lindsay JG, Beal MF, Gibson GE.

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy.

J Neurosci Res. 2001 Dec 1;66(5):1028-34.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Zhang H, Gibson GE.

Co-culture with astrocytes or microglia protects metabolically impaired neurons.

Mech Ageing Dev. 2001 Dec;123(1):21-7.

Abstract on PubMed

PUBLICATION:

Journal Article

Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL, Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF.

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Ann Neurol. 2001 Jul;50(1):112-7.

Abstract on PubMed

PUBLICATION:

Journal Article

Simon DK, Lin MT, Ahn CH, Liu GJ, Gibson GE, Beal MF, Johns DR.

Low mutational burden of individual acquired mitochondrial DNA mutations in brain.

Genomics. 2001 Apr 1;73(1):113-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH.

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism.

J Neurochem. 2001 Feb;76(4):1010-21.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Zhang H.

Advances in Ginkgo Biloba Extract Research: Effects of Ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer’s Disease patients and controls

Christen Y, Editeur S, editors. Marseille: Ipsen Foundation; 2001. Effects of Ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer’s Disease patients and controls ; p.108-121.

PUBLICATION:

Journal Article

Calingasan NY, Gibson GE.

Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism.

Brain Res. 2000 Dec 1;885(1):62-9.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Zhang H, Sheu KR, Park LC.

Differential alterations in antioxidant capacity in cells from Alzheimer patients.

Biochim Biophys Acta. 2000 Nov 15;1502(3):319-29.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Haroutunian V, Zhang H, Park LC, Shi Q, Lesser M, Mohs RC, Sheu RK, Blass JP.

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

Ann Neurol. 2000 Sep;48(3):297-303.

Abstract on PubMed

PUBLICATION:

Journal Article

Murphy EJ, Zhang H, Sorbi S, Rapoport SI, Gibson GE.

Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations.

Brain Res Bull. 2000 Jun;52(3):207-12.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Sheu RK, Gibson GE.

Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise.

Ann N Y Acad Sci. 2000 Apr;903:204-21. Review.

Abstract on PubMed

PUBLICATION:

Review

Calingasan NY, Gibson GE.

Vascular endothelium is a site of free radical production and inflammation in areas of neuronal loss in thiamine-deficient brain.

Ann N Y Acad Sci. 2000 Apr;903:353-6. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Huang PL, Chun HS, Fabian A, Gibson GE.

Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

J Neuropathol Exp Neurol. 2000 Mar;59(3):207-17.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Park LC, Sheu KF, Blass JP, Calingasan NY.

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration.

Neurochem Int. 2000 Feb;36(2):97-112. Review.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Park LC, Zhang H, Sorbi S, Calingasan NY.

Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits.

Ann N Y Acad Sci. 1999;893:79-94. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Albers DS, Augood SJ, Park LC, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsattel JP, Gibson GE, Beal MF.

Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment.

J Neurochem. 2000 Feb;74(2):878-81.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Calingasan NY, Uchida K, Zhang H, Gibson GE.

Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture.

J Neurochem. 2000 Jan;74(1):114-24.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Calingasan NY, Sheu KF, Gibson GE.

Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells.

Anal Biochem. 2000 Jan 1;277(1):86-93.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Gibson GE, Bunik V, Cooper AJ.

Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.

Biochem Pharmacol. 1999 Nov 15;58(10):1557-65.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Chun WJ, Park LC, Uchida K, Gibson GE.

Oxidative stress is associated with region-specific neuronal death during thiamine deficiency.

J Neuropathol Exp Neurol. 1999 Sep;58(9):946-58.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Gibson GE.

Cerebrometabolic aspects of delirium in relationship to dementia.

Dement Geriatr Cogn Disord. 1999 Sep-Oct;10(5):335-8. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Park LC, Zhang H, Sheu KF, Calingasan NY, Kristal BS, Lindsay JG, Gibson GE.

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.

J Neurochem. 1999 May;72(5):1948-58.

Abstract on PubMed

PUBLICATION:

Journal Article

Conti B, Park LC, Calingasan NY, Kim Y, Kim H, Bae Y, Gibson GE, Joh TH.

Cultures of astrocytes and microglia express interleukin 18.

Brain Res Mol Brain Res. 1999 Apr 6;67(1):46-52.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Uchida K, Gibson GE.

Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.

J Neurochem. 1999 Feb;72(2):751-6.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Sheu KF, Blass JP.

Abnormalities of mitochondrial enzymes in Alzheimer disease.

J Neural Transm (Vienna). 1998;105(8-9):855-70. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Park LC, Gandy SE, Gibson GE.

Disturbances of the blood-brain barrier without expression of amyloid precursor protein- containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs.

Dev Neurosci. 1998;20(4-5):454-61.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Zhang H, Sheu KF, Bogdanovich N, Lindsay JG, Lannfelt L, Vestling M, Cowburn RF.

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation.

Ann Neurol. 1998 Oct;44(4):676-81.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Park LC, Calo LL, Trifiletti RR, Gandy SE, Gibson GE.

Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism.

Am J Pathol. 1998 Aug;153(2):599-610.

Full-Text on PubMed

PUBLICATION:

Journal Article

Sheu KF, Calingasan NY, Lindsay JG, Gibson GE.

Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.

J Neurochem. 1998 Mar;70(3):1143-50.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Vestling M, Zhang H, Szolosi S, Alkon D, Lannfelt L, Gandy S, Cowburn RF.

Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.

Neurobiol Aging. 1997 Nov-Dec;18(6):573-80.

Abstract on PubMed

PUBLICATION:

Review

Gasparini L, Racchi M, Binetti G, Trabucchi M, Solerte SB, Alkon D, Etcheberrigaray R, Gibson G, Blass J, Paoletti R, Govoni S.

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease.

FASEB J. 1998 Jan;12(1):17-34. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Tofel-Grehl B, Scheffold K, Cristofalo VJ, Blass JP.

A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts.

Age (Omaha). 1998 Jan;21(1):7-14. doi: 10.1007/s11357-998-0002-z.

Full-Text on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Blass JP.

Basic Neurochemistry: Nutrition and Brain Function

Siegel GF, Agranoff B, Albers W, Fischer SK, Uhler M, editors. Second ed. Siegel GF, Agranoff B, Albers W, Fischer SK, Uhler M, editors. NY: Springer; 1998. Nutrition and Brain Function; p.691-710

PUBLICATION:

Journal Article

Gibson GE, Calingasan NY, Baker H, Gandy S, Sheu KF.

Importance of vascular changes in selective neurodegeneration with thiamine deficiency.

Ann N Y Acad Sci. 1997 Sep 26;826:516-9.

Abstract on PubMed

PUBLICATION:

Journal Article

Shanahan C, Gibson GE, Cowburn RF, Johnston JA, Wiehager B, Lannfelt L, O'Neill C.

G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation.

Neurosci Lett. 1997 Aug 22;232(1):33-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson G, Toral-Barza L, Zhang H.

Selective changes in cell bodies and growth cones of nerve growth factor-differentiated PC12 cells induced by chemical hypoxia.

J Neurochem. 1997 Aug;69(2):603-11.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Gandy SE, Gibson GE.

Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions.

Neuroreport. 1997 Jul 28;8(11):2631-4.

Abstract on PubMed

PUBLICATION:

Journal Article

Vestling M, Adem A, Racchi M, Gibson GE, Lannfelt L, Cowburn RF.

Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.

Neuroreport. 1997 May 27;8(8):2031-5.

Abstract on PubMed

PUBLICATION:

Journal Article

Zhang F, Carson Rc, Zhang H, Gibson GE, Thomas HM.

Pulmonary artery smooth muscle cell contraction and intracellular calcium: responses to diphenyleneiodonium and hypoxia.

American Journal of Physiology (Lung Cell. Mol. Physiol.). 1997; 17:L603-L611.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Gibson GE, Sheu KF.

Peripheral markers of Alzheimer's disease.

Aging (Milano). 1997;9(4 Suppl):55-6. Review. No abstract available.

PUBLICATION:

Book Chapter

Blass JP, Gibson GE.

Advances in Cell Aging and Gerontology: Metabolism of the Aging Brain

Mattson MP, editor. New York: Springer; 1997. Metabolism of the Aging Brain; p.109-128.

PUBLICATION:

Journal Article

Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE.

Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.

Am J Pathol. 1996 Sep;149(3):1063-71.

Full-Text on PubMed

PUBLICATION:

Journal Article

Sheu KF, Calingasan NY, Dienel GA, Baker H, Jung EH, Kim KS, Paoletti F, Gibson GE.

Regional reductions of transketolase in thiamine-deficient rat brain.

J Neurochem. 1996 Aug;67(2):684-91.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Zhang H, Toral-Barza L, Szolosi S, Tofel-Grehl B.

Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease.

Biochim Biophys Acta. 1996 Jun 7;1316(2):71-7.

Abstract on PubMed

PUBLICATION:

Review

Gibson G, Martins R, Blass J, Gandy S.

Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients.

Life Sci. 1996;59(5-6):477-89. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Gibson G.

Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts.

Life Sci. 1996;59(18):1533-43.

Abstract on PubMed

PUBLICATION:

Journal Article

Etchegerrigaray R, Ito E, Tofel-Grehl B, Gibson GE, Alkon DL.

New implications of memory mechanisms for Alzheimer's Disease

Neuroscience research communications. 1993; 13S1:S7.

Abstract on WASEDA University

PUBLICATION:

Book Chapter

Sheu KF, Calingasan NY, Jung EH, Gibson GE.

Biochemistry and Physiology of Thiamine Diphosphate Enzymes: Transketolase in thiamine deficiency-induced model of metabolic encephalopathy

Bisswanger H, Shellenberger A, editors. Germany: VCH Publishers; 1996. Transketolase in thiamine deficiency-induced model of metabolic encephalopathy ; p.446-451.

PUBLICATION:

Journal Article

Martins RN, Turner BA, Carroll RT, Sweeney D, Kim KS, Wisniewski HM, Blass JP, Gibson GE, Gandy S.

High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells.

Neuroreport. 1995 Dec 29;7(1):217-20.

Abstract on PubMed

PUBLICATION:

Journal Article

Kim KS, Huang HM, Zhang H, Wagner J, Joh T, Gibson GE.

The role of signal transduction systems in mediating cell density dependent changes in tyrosine hydroxylase gene expression.

Brain Res Mol Brain Res. 1995 Nov;33(2):254-60.

Abstract on PubMed

PUBLICATION:

Journal Article

Dienel GA, Tofel-Grehl B, Cruz CC, Luludis K, Pettigrew K, Sokoloff L, Gibson GE.

Determination of local rates of 45Ca influx into rat brain by quantitative autoradiography: studies of aging.

Am J Physiol. 1995 Aug;269(2 Pt 2):R453-62.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Baker H, Sheu KF, Gibson GE.

Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency.

Exp Neurol. 1995 Jul;134(1):64-72.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Gandy SE, Baker H, Sheu KF, Kim KS, Wisniewski HM, Gibson GE.

Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency.

Brain Res. 1995 Apr 17;677(1):50-60.

Abstract on PubMed

PUBLICATION:

Journal Article

Aisen ML, Sevilla D, Gibson G, Kutt H, Blau A, Edelstein L, Hatch J, Blass J.

3,4-diaminopyridine as a treatment for amyotrophic lateral sclerosis.

J Neurol Sci. 1995 Mar;129(1):21-4.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Sheu KF, Baker H, Jung EH, Paoletti F, Gibson GE.

Heterogeneous expression of transketolase in rat brain.

J Neurochem. 1995 Mar;64(3):1034-44.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Lin TA, Sun GY, Gibson GE.

Increased inositol 1,4,5-trisphosphate accumulation correlates with an up-regulation of bradykinin receptors in Alzheimer's disease.

J Neurochem. 1995 Feb;64(2):761-6.

Abstract on PubMed

PUBLICATION:

Book Chapter

Calingasan Ny, Baker H, Sheu KF, Gandy SE, Gibson GE.

Neurodegenerative Diseases: Thiamine deficiency as a model of selective neurodegeneration with chronic oxidative deficits.

Fiskum G, editor. New York: Plenum Press; 1995. Thiamine deficiency as a model of selective neurodegeneration with chronic oxidative deficits.; p.193-201.

PUBLICATION:

Review

Etcheberrigaray E, Gibson GE, Alkon DL.

Molecular mechanisms of memory and the pathophysiology of Alzheimer's disease.

Ann N Y Acad Sci. 1994 Dec 15;747:245-55. Review.

Abstract on PubMed

PUBLICATION:

Review

Huang HM, Martins R, Gandy S, Etcheberrigaray R, Ito E, Alkon DL, Blass J, Gibson G.

Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease.

Ann N Y Acad Sci. 1994 Dec 15;747:225-44. Review. No abstract available.

PUBLICATION:

Journal Article

Föhr UG, Gibson GE, Tofel-Grehl B, Schäfer BW, Heizmann CW.

Expression of intracellular calcium-binding proteins in cultured skin fibroblasts from Alzheimer and normal aged donors.

Biochim Biophys Acta. 1994 Sep 29;1223(3):391-7.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Baker H, Sheu KF, Gibson GE.

Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain.

J Comp Neurol. 1994 Aug 15;346(3):461-79.

Abstract on PubMed

PUBLICATION:

Review

Goldman JE, Calingasan NY, Gibson GE.

Aging and the brain.

Curr Opin Neurol. 1994 Aug;7(4):287-93. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Calingasan NY, Baker H, Sheu KF, Gibson GE.

Selective enrichment of cholinergic neurons with the alpha-ketoglutarate dehydrogenase complex in rat brain.

Neurosci Lett. 1994 Feb 28;168(1-2):209-12.

Abstract on PubMed

PUBLICATION:

Journal Article

Ito E, Oka K, Etcheberrigaray R, Nelson TJ, McPhie DL, Tofel-Grehl B, Gibson GE, Alkon DL.

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):534-8.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Toral-Barza L, Sheu KF, Gibson GE.

The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes.

Neurochem Res. 1994 Jan;19(1):89-95.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Calinasan NY, Baker H, Sheu RK.

Age and nutrition in models of neurological disease

Urbana, Illinois: University of Illinois; 1994. Age and nutrition in models of neurological disease; p.29-40.

PUBLICATION:

Journal Article

Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL.

Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8209-13.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Gibson GE.

Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors.

J Biol Chem. 1993 Jul 15;268(20):14616-21.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Huang HM.

Drugs in Development: Changes in signal transduction systems, including calcium, with aging and Alzheimer's disease.

New York: Springer; 1993. Chapter 2, Changes in signal transduction systems, including calcium, with aging and Alzheimer's disease. ; p.15-17.

PUBLICATION:

Journal Article

Carroll JM, Toral-Barza L, Gibson G.

Cytosolic free calcium and gene expression during chemical hypoxia.

J Neurochem. 1992 Nov;59(5):1836-43.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Nielsen P, Toral-Barza L.

Synaptosomal plasma and mitochondrial membrane potentials during anoxia.

Neurosci Lett. 1992 Apr 13;138(1):133-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Toral-Barza L.

Cytosolic free calcium in lymphoblasts from young, aged and Alzheimer subjects.

Mech Ageing Dev. 1992 Mar 15;63(1):1-9.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Gibson GE.

Nonneural markers in Alzheimer disease.

Alzheimer Dis Assoc Disord. 1992 Winter;6(4):205-24. Review.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Sheu KF, Cooper AJ, Jung EH, Gibson GE.

Thiamin and Alzheimer's disease.

J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:401-4. Review.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Huang HM.

Neuromethods Vol 22 Animal models of brain hypoxia

Boulton AA, Baker GB, Butterworth RF, editors. Totawa, NJ: Humana Press; 1992. Animal models of brain hypoxia; p.51-93.

PUBLICATION:

Journal Article

Sherman KA, Gibson GE, Perrino P, Garrett K.

Acetylcholine formation from glucose following acute choline supplementation.

Neurochem Res. 1991 Sep;16(9):1009-15.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Toral-Barza L, Thaler H, Tofel-Grehl B, Gibson GE.

Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors.

Neurobiol Aging. 1991 Sep-Oct;12(5):469-73.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson G, Toral-Barza L, Huang HM.

Cytosolic free calcium concentrations in synaptosomes during histotoxic hypoxia.

Neurochem Res. 1991 Apr;16(4):461-7.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Toral-Barza L, Gibson GE.

Interactions between inositol phosphates and cytosolic free calcium following bradykinin stimulation in cultured human skin fibroblasts.

Biochim Biophys Acta. 1991 Feb 19;1091(3):409-16.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Toral-Barza L, Gibson G.

Cytosolic free calcium and ATP in synaptosomes after ischemia.

Life Sci. 1991;48(15):1439-45.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Blass JP, Huang HM, Freeman GB.

The cellular basis of delirium and its relevance to age-related disorders including Alzheimer's disease.

Int Psychogeriatr. 1991 Winter;3(2):373-95. Review.

Abstract on PubMed

PUBLICATION:

Review

Blass JP, Gibson GE.

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

Rev Neurol (Paris). 1991;147(6-7):513-25. Review.

Abstract on PubMed

PUBLICATION:

Book Chapter

Blass JP, Gibson GE, Black RS, Ko L.

Biological Markers In Dementia of Alzheimer Type: Cultured skin fibroblasts

Carlson LA, Gottfries CG, Winblad B, editors. London: Smith-Gordon; 1990. Cultured skin fibroblasts; p.203-214.

PUBLICATION:

Journal Article

Gibson G.

Causes of cell damage in hypoxia/ischemia, aging and Alzheimer's disease.

Neurobiol Aging. 1989 Sep-Oct;10(5):608-9; discussion 618-20.

Abstract on PubMed

PUBLICATION:

Journal Article

Broderick PA, Gibson GE.

Dopamine and serotonin in rat striatum during in vivo hypoxic-hypoxia.

Metab Brain Dis. 1989 Jun;4(2):143-53.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Manger T, Toral-Barza L, Freeman G.

Cytosolic-free calcium and neurotransmitter release with decreased availability of glucose or oxygen.

Neurochem Res. 1989 May;14(5):437-43.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Gibson GE.

Phosphatidylinositol metabolism during in vitro hypoxia.

J Neurochem. 1989 Mar;52(3):830-5.

Abstract on PubMed

PUBLICATION:

Journal Article

Huang HM, Gibson GE.

Effects of in vitro hypoxia on depolarization-stimulated accumulation of inositol phosphates in synaptosomes.

Life Sci. 1989;45(16):1443-9.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson G, Nielsen P, Mykytyn V, Carlson K, Blass J.

Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency.

Neurochem Res. 1989 Jan;14(1):17-24.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Toral-Barza L, Manger T, Freeman G.

Cerebral Ischemia and Calcium: Neurotransmitters and calcium during hypoxia.

Hartman A, Kuchinsky W, editors. New York: Springer-Verlag; 1989. Neurotransmitters and calcium during hypoxia.

PUBLICATION:

Journal Article

Gibson GE, Manger T.

Changes in cytosolic free calcium with 1,2,3,4-tetrahydro-5-aminoacridine, 4-aminopyridine and 3,4-diaminopyridine.

Biochem Pharmacol. 1988 Nov 1;37(21):4191-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, Perrino P.

Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease.

Arch Neurol. 1988 Aug;45(8):836-40.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Freeman GB, Mykytyn V.

Selective damage in striatum and hippocampus with in vitro anoxia.

Neurochem Res. 1988 Apr;13(4):329-35.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Mykytyn V.

An in vitro model of anoxic-induced damage in mouse brain.

Neurochem Res. 1988 Jan;13(1):9-20.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Gibson GE.

Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates.

Ann N Y Acad Sci. 1988;515:191-202.

Abstract on PubMed

PUBLICATION:

Book Chapter

Blass JP, Gibson GE.

Etiology of Dementia of Alzheimer's Type

Hendersen AS, Hendersen JH, editors. Germany: Dahlem Konferenzen; 1988. Aging and the Brain

PUBLICATION:

Journal Article

Freeman GB, Mykytyn V, Gibson GE.

Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and/or 3,4-diaminopyridine treatment.

Neurochem Res. 1987 Nov;12(11):1019-27.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Nielsen P, Sherman KA, Blass JP.

Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients.

Biol Psychiatry. 1987 Sep;22(9):1079-86.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Nielsen PE, Gibson GE.

Effect of age on behavioral and enzymatic changes during thiamin deficiency.

Neurobiol Aging. 1987 Sep-Oct;8(5):429-34.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Peterson C.

Calcium and the aging nervous system.

Neurobiol Aging. 1987 Jul-Aug;8(4):329-43. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Gibson GE.

Selective alteration of mouse brain neurotransmitter release with age.

Neurobiol Aging. 1987 Mar-Apr;8(2):147-52.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Sherman KA, Gibson GE.

Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions.

Pharmacol Biochem Behav. 1987 Feb;26(2):305-12.

Abstract on PubMed

PUBLICATION:

Book Chapter

Peterson C, Gibson GE.

Cellular and Molecular Mechanisms for Cholinergic Function: Nerve ending acetylcholine metabolism and calcium homeostasis during hypoxia.

Dowdall M, Hawthorne J, editors. Chinchester, England: Ellis Horwood Ltd; 1987. Nerve ending acetylcholine metabolism and calcium homeostasis during hypoxia.; p.720-725.

PUBLICATION:

Book Chapter

Gibson GE, Peterson C, Freeman G.

Molecular Neuropathology of Aging: Alterations in neurotransmitter metabolism and calcium homeostasis during aging and Alzheimer's disease.

Davies P, Finch CE, editors. New York: Banbury Reports; 1987. Alterations in neurotransmitter metabolism and calcium homeostasis during aging and Alzheimer's disease.; p.89-96.

PUBLICATION:

Journal Article

Freeman GB, Gibson GE.

Effect of decreased oxygen on in vitro release of endogenous 3,4-dihydroxyphenylethylamine from mouse striatum.

J Neurochem. 1986 Dec;47(6):1924-31.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson G, Perrino P, Dienel GA.

In vivo brain calcium homeostasis during aging.

Mech Ageing Dev. 1986 Nov 28;37(1):1-12.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Nielsen P, Gibson GE.

Behavioral and neurochemical correlates of morphine and hypoxia interactions.

Pharmacol Biochem Behav. 1986 Jun;24(6):1687-93.

Abstract on PubMed

PUBLICATION:

Journal Article

Sherman KA, Gibson GE, Blass JP.

Human red blood cell choline uptake with age and Alzheimer's disease.

Neurobiol Aging. 1986 May-Jun;7(3):205-9.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Nielsen P, Gibson GE.

Monoamine neurotransmitter metabolism and locomotor activity during chemical hypoxia.

J Neurochem. 1986 Mar;46(3):733-8.

Abstract on PubMed

PUBLICATION:

Journal Article

Freeman GB, Nielsen P, Gibson GE.

Automated method to estimate catecholamine and indoleamine content and turnover rates.

J Chromatogr. 1986 Jan 24;374(2):239-49.

Abstract on PubMed

PUBLICATION:

Book Chapter

Blass JP, Baker A, Balin A, Barclay LL, Gibson GE, Peterson C, Sims NR.

Alzheimer's and Parkinson's Disease

Fischer AF, Hanin I, Lachman C, editors. New York: Plenum Press; 1986. Biological markers for Alzheimer's disease. ; p.299-308.

PUBLICATION:

Book Chapter

Gibson GE, Peterson C.

Dynamics of Cholinergic Function: Interactions of calcium homeostasis, acetylcholine metabolism, behavior and 3,4 diaminopyridine during aging.

Crook T, Bartus R, Ferris S, Gerson S, editors. Connecticut: Mark Powley Associates; 1986. Consideration of neurotransmitters and calcium metabolism in therapeutic design; p.499-517.

PUBLICATION:

Book Chapter

Gibson GE, Peterson C.

Modifications of cell to cell signals during normal and pathological aging: Changes in calcium homeostasis during aging.

9S ed. Govoni S, Battaini F, editors. New York: NATO; 1986. Changes in calcium homeostasis during aging. ; p.123-140.

PUBLICATION:

Journal Article

Peterson C, Nicholls DG, Gibson GE.

Subsynaptosomal calcium distribution during hypoxia and 3,4-diaminopyridine treatment.

J Neurochem. 1985 Dec;45(6):1779-90.

Abstract on PubMed

PUBLICATION:

Journal Article

Peterson C, Gibson GE, Blass JP.

Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease.

N Engl J Med. 1985 Apr 18;312(16):1063-5. No abstract available.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Blass JP.

Oxidative metabolism and acetylcholine synthesis during acetylpyridine treatment.

Neurochem Res. 1985 Apr;10(4):453-67.

Abstract on PubMed

PUBLICATION:

Journal Article

Ghajar JB, Gibson GE, Duffy TE.

Regional acetylcholine metabolism in brain during acute hypoglycemia and recovery.

J Neurochem. 1985 Jan;44(1):94-8.

Abstract on PubMed

PUBLICATION:

Journal Article

Peterson C, Nicholls DG, Gibson GE.

Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment.

Neurobiol Aging. 1985 Winter;6(4):297-304.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE. McCandless DW, editor.

Cerebral Energy Metabolism and Metabolic Encephalopathy: Hypoxia

New York: Plenum Press; 1985. Hypoxia; p.43-78.

eBook on Springer

PUBLICATION:

Journal Article

Hirsch JA, Gibson GE.

Selective alteration of neurotransmitter release by low oxygen in vitro.

Neurochem Res. 1984 Aug;9(8):1039-49.

Abstract on PubMed

PUBLICATION:

Journal Article

Hirsch JA, Gibson GE.

Thiamin antagonists and the release of acetylcholine and norepinephrine from brain slices.

Biochem Pharmacol. 1984 Jul 15;33(14):2325-7. No abstract available.

Abstract on PubMed

PUBLICATION:

Journal Article

Ksiezak-Reding H, Peterson C, Gibson GE.

The pyruvate dehydrogenase complex during aging.

Mech Ageing Dev. 1984 Jul;26(1):67-73.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Ksiezak-Reding H, Sheu KF, Mykytyn V, Blass JP.

Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal.

Neurochem Res. 1984 Jun;9(6):803-14.

Abstract on PubMed

PUBLICATION:

Journal Article

Peterson C, Gibson GE.

Synaptosomal calcium metabolism during hypoxia and 3,4-diaminopyridine treatment.

J Neurochem. 1984 Jan;42(1):248-53.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Peterson C. Samual D, Algeri A, Gershon S, Grimm V, Toffano G, editors.

Aging of the Brain: Amelioration of age related deficits in acetylcholine release and behavior with 3,4 diaminopyridine.

New York: Raven Press; 1984. Amelioration of age related deficits in acetylcholine release and behavior with 3,4 diaminopyridine. ; p.337-348.

PUBLICATION:

Book Chapter

Gibson GE, Peterson C. Crook T, Ferris S, Bartus R, editors.

Assessment in Geriatric Psychopharmacology: Pharmacological approaches to age related deficts in oxidative metabolism. In: Geriatric Psychopharmacology.

Connecticut: Mark Powley Associates; 1984. Pharmacological approaches to age related deficts in oxidative metabolism. In: Geriatric Psychopharmacology; p.323-343.

PUBLICATION:

Journal Article

Peterson C, Gibson GE.

Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake.

J Biol Chem. 1983 Oct 10;258(19):11482-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Pelmas CJ, Peterson C.

Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.

Pharmacol Biochem Behav. 1983 Jun;18(6):909-16.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Pelmas C, Blass JP.

A central cholinergic deficit in rats with dietary thiamin deficiency

Neurochem. Pathol. June 1983; 1:125-135.

Abstract on Springer

PUBLICATION:

Journal Article

Gibson GE, Peterson C.

Acetylcholine and oxidative metabolism in septum and hippocampus in vitro.

J Biol Chem. 1983 Jan 25;258(2):1142-5.

Abstract on PubMed

PUBLICATION:

Journal Article

Peterson C, Gibson GE.

Amelioration of age-related neurochemical and behavioral deficits by 3,4-diaminopyridine.

Neurobiol Aging. 1983 Spring;4(1):25-30.

Abstract on PubMed

PUBLICATION:

Journal Article

Davis HP, Idowu A, Gibson GE.

Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine.

Exp Aging Res. 1983 Fall;9(3):211-4.

Abstract on PubMed

PUBLICATION:

Book Chapter

Gibson GE, Blass JP.

Handbook of Neurochemistry: Metabolism and neurotransmission.

Lajtha A, editor. New York: Plenum Press; 1983. Metabolism and neurotransmission. ; p.633-651.

PUBLICATION:

Journal Article

Barclay LL, Gibson GE, Blass JP.

Cholinergic therapy of abnormal open-field behavior in thiamin-deficient rats.

J Nutr. 1982 Oct;112(10):1906-13.

Abstract on PubMed

PUBLICATION:

Journal Article

Barclay LL, Gibson GE.

Spontaneous open-field behavior in thiamin-deficient rats.

J Nutr. 1982 Oct;112(10):1899-905.

Abstract on PubMed

PUBLICATION:

Journal Article

Peterson C, Gibson GE.

3,4-diaminopyridine alters acetylcholine metabolism and behavior during hypoxia.

J Pharmacol Exp Ther. 1982 Sep;222(3):576-82.

Abstract on PubMed

PUBLICATION:

Journal Article

Ksiezak-Reding H, Blass JP, Gibson GE.

Studies on the pyruvate dehydrogenase complex in brain with the arylamine acetyltransferase-coupled assay.

J Neurochem. 1982 Jun;38(6):1627-36.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Peterson C.

Decreases in the release of acetylcholine in vitro with low oxygen.

Biochem Pharmacol. 1982 Jan 1;31(1):111-5. No abstract available.

PUBLICATION:

Journal Article

Gibson GE, Peterson C.

Neurotransmitter and carbohydrate metabolism during senescence.

Exp Brain Res. 1982;Suppl 5:133-9. No abstract available.

PUBLICATION:

Review

Gibson G, Barclay L, Blass J.

The role of the cholinergic system in thiamin deficiency.

Ann N Y Acad Sci. 1982;378:382-403. Review. No abstract available.

PUBLICATION:

Book Chapter

Gibson GE

Progress in Cholinergic Biology: Model Cholinergic Synapses

Giacobini E, Filogamo G, Giacobini G, Vernadakis A, editors. New York: Raven Press; 1982. Biochemical and behavioral parallels in aging and hypoxia; p.107-122. 107-122p.

PUBLICATION:

Book Chapter

Gibson GE, Peterson C.

Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System: Biochemical and behavioral parallels in aging and hypoxia

Giacobini E, Filogamo G, Giacobini G, Vernadakis A, editors. New York: Raven Press; 1982. Biochemical and behavioral parallels in aging and hypoxia; p.107-122. 107-122p.

PUBLICATION:

Journal Article

Gibson GE, Peterson C.

Aging decreases oxidative metabolism and the release and synthesis of acetylcholine.

J Neurochem. 1981 Oct;37(4):978-84.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Peterson C, Jenden DJ.

Brain acetylcholine synthesis declines with senescence.

Science. 1981 Aug 7;213(4508):674-6.

Abstract on PubMed

PUBLICATION:

Journal Article

Ksiezak HJ, Gibson GE.

Oxygen dependence of glucose and acetylcholine metabolism in slices and synaptosomes from rat brain.

J Neurochem. 1981 Aug;37(2):305-14.

Abstract on PubMed

PUBLICATION:

Journal Article

Ksiezak HJ, Gibson GE.

Acetylcholine synthesis and CO2 production from variously labeled glucose in rat brain slices and synaptosomes.

J Neurochem. 1981 Jul;37(1):88-94.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Peterson C, Sansone J.

Decreases in amino acids and acetylcholine metabolism during hypoxia.

J Neurochem. 1981 Jul;37(1):192-201.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Pulsinelli W, Blass JP, Duffy TE.

Brain dysfunction in mild to moderate hypoxia.

Am J Med. 1981 Jun;70(6):1247-54.

Abstract on PubMed

PUBLICATION:

Journal Article

Barclay LL, Gibson GE, Blass JP.

Impairment of behavior and acetylcholine metabolism in thiamine deficiency.

J Pharmacol Exp Ther. 1981 Jun;217(3):537-43.

Abstract on PubMed

PUBLICATION:

Journal Article

Barclay LL, Gibson GE, Blass JP.

The string test: an early behavioral change in thiamine deficiency.

Pharmacol Biochem Behav. 1981 Feb;14(2):153-7.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Duffy TE.

Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide.

J Neurochem. 1981 Jan;36(1):28-33.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Peterson C, Sansone J.

Neurotransmitter and carbohydrate metabolism during aging and mild hypoxia.

Neurobiol Aging. 1981 Fall;2(3):165-72.

Abstract on PubMed

PUBLICATION:

Book Chapter

Blass JP, Gibson GE, Duffy TE, Plum F.

Cholinergic Mecha¬nisms: Phylogenetic Aspects, Central and Peripheral Synapses, and Clinical Significance; Cholinergic dysfunction: a common denominator in metabolic encephalopathies.

Pepeu G, Ladinsky H, editors. NY: Plenum Press; 1981. Cholinergic dysfunction: a common denominator in metabolic encephalopathies. ; p.921-928.

eBook on Springer

PUBLICATION:

Book Chapter

Gibson GE, Ksiezak HJ, Duffy TE.

Cholinergic Mechanisms: Phylogenetic Aspects, Central and Peripheral Synapses, and Clinical Significance; Acetylcholine synthesis and glucose oxidation with various oxygen levels in vivo and in vitro.

Pepeu G, Ladinsky H, editors. New York: Plenum Press; 1981. Acetylcholine synthesis and glucose oxidation with various oxygen levels in vivo and in vitro. ; p.443-449.

eBook on Springer

PUBLICATION:

Journal Article

Gibson GE, Shimada M.

Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis.

Biochem Pharmacol. 1980 Feb;29(2):167-74. No abstract available.

Abstract on PubMed

PUBLICATION:

Book Chapter

Blass JP, Gibson GE, Shimada M, Kihara T, Watanabe M, Kurinioto K.

Biochemistry of Dementia: Brain carbohydrate metabolism and dementia.

Roberts PJ, editor. London: J Wiley; 1980. Brain carbohydrate metabolism and dementia

PUBLICATION:

Book Chapter

Gibson GE, Duffy TE, Plum F.

Cerebral Circulation and Neurotransmitters: Cholinergic dysfunction: a common denominator in metabolic encephalopathies.

Bes A, Gerard G, editors. Amsterdam: Excerpta Medica; 1980. Cholinergic dysfunction: a common denominator in metabolic encephalopathies; p.199-201.

PUBLICATION:

Review

Blass JP, Gibson GE.

Genetic factors in Wernicke-Korsakoff syndrome.

Alcohol Clin Exp Res. 1979 Apr;3(2):126-34. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Shimada M, Blass JP.

Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia.

Biochem Pharmacol. 1979 Mar 15;28(6):747-50. No abstract available.

Abstract on PubMed

PUBLICATION:

Journal Article

Blass JP, Gibson GE.

Consequences of mild, graded hypoxia.

Adv Neurol. 1979;26:229-50. No abstract available.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Blass JP.

Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices.

Biochem Pharmacol. 1979;28(1):133-9. No abstract available.

PUBLICATION:

Book Chapter

Blass JP, Gibson GE.

Brain Acetylcholine and Neuropsychiatric Disease: Carbohydrates and acetylcholine synthesis: implications for cognitive disorders.

Davis KL, Berger PA, editors. New York: Plenum Press; 1979. Carbohydrates and acetylcholine synthesis: implications for cognitive disorders; p.215-236.

PUBLICATION:

Journal Article

Gibson GE, Shimada M, Blass JP.

Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia.

J Neurochem. 1978 Oct;31(4):757-60. No abstract available.

PUBLICATION:

Journal Article

Gibson GE, Blass JP, Jenden DJ.

Measurement of acetylcholine turnover with glucose used as precursor: evidence for compartmentation of glucose metabolism in brain.

J Neurochem. 1978 Jan;30(1):71-6. No abstract available.

PUBLICATION:

Review

Blass JP, Gibson GE.

Studies of the pathophysiology of pyruvate dehydrogenase deficiency.

Adv Neurol. 1978;21:181-9. Review. No abstract available.

PUBLICATION:

Book Chapter

Blass JP, Gibson GE.

Cholinergic Mechanisms and Psychopharmacology: Cholinergic systems and disorders of carbohydrate catabolism.

Jenden DJ, editor. NY: Plenum Press; 1978. Cholinergic systems and disorders of carbohydrate catabolism; p.791-804.

PUBLICATION:

Journal Article

Blass JP, Gibson GE.

Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome.

N Engl J Med. 1977 Dec 22;297(25):1367-70.

Abstract on PubMed

PUBLICATION:

Journal Article

Falk RE, Cederbaum SD, Blass JP, Gibson GE, Kark RA, Carrel RE.

Ketonic diet in the management of pyruvate dehydrogenase deficiency.

Pediatrics. 1976 Nov;58(5):713-21.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson G, Blass JP.

A relation between (NAD+)/(NADH) potentials and glucose utilization in rat brain slices.

J Biol Chem. 1976 Jul 10;251(13):4127-30.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Blass JP.

Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia.

J Neurochem. 1976 Jul;27(1):37-42. No abstract available.

PUBLICATION:

Journal Article

Gibson GE, Blass JP.

Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites.

J Neurochem. 1976 Jun;26(6):1073-8. No abstract available.

PUBLICATION:

Journal Article

Kark RA, Brown WJ, Edgerton VR, Reynolds SF, Gibson G.

Experimental thiamine deficiency. Neuropathic and mitochondrial changes induced in rat muscle.

Arch Neurol. 1975 Dec;32(12):818-25.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Jope R, Blass JP.

Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces.

Biochem J. 1975 Apr;148(1):17-23.

Full-Text on PubMed

PUBLICATION:

Book Chapter

Blass JP, Cedebbaum SD, Gibson GE.

Normal Pathological Development of Energy Metabolism: Clincal and metabolic abnormalities accompanying deficiencies in pyruvate oxidation.

Hommes FJ, Van den Berg CI, editors. New York: Academic Press; 1975. Clincal and metabolic abnormalities accompanying deficiencies in pyruvate oxidation.; p.193-210.

PUBLICATION:

Journal Article

Gibson GE, Zimber A, Krook L, Richardson EP, Visek WJ.

Brain histology and behavior of mice injected with urease.

J Neuropathol Exp Neurol. 1974 Apr;33(2):201-11. No abstract available.

PUBLICATION:

Journal Article

Prior RL, Clifford AJ, Gibson GE, Visek WJ.

Effects of insulin on glucose metabolism in hyperammonemic rats.

Am J Physiol. 1971 Aug;221(2):432-6. No abstract available.

PUBLICATION:

Book Chapter

Blass JP, Gibson GE, Kark R.

Thiamine: Pyruvate decarboxylase deficiency.

Gubler C, Fujiwara M, Dreyfus P, editors. New York: John Wiley & Sons; 1946. Pyruvate decarboxylase deficiency. ; p.321-334.