Publications for Brett C. Langley, Ph.D.

Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR.

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595.

Full-Text on PubMed

PUBLICATION:

Review

Brochier C, Langley B.

Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases.

Neurotherapeutics. 2013 Oct;10(4):817-30. doi: 10.1007/s13311-013-0210-9. Review.

Full-Text on PubMed

PUBLICATION:

Review

Langley B, Sauve A.

Sirtuin deacetylases as therapeutic targets in the nervous system.

Neurotherapeutics. 2013 Oct;10(4):605-20. doi: 10.1007/s13311-013-0214-5. Review.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Brochier C, Dennis G, Rivieccio MA, McLaughlin K, Coppola G, Ratan RR, Langley B.

Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.

J Neurosci. 2013 May 15;33(20):8621-32. doi: 10.1523/JNEUROSCI.5214-12.2013.

Abstract on PubMed

Willis Lab / Ratan Lab

PUBLICATION:

Journal Article

Ma TC, Langley B, Ko B, Wei N, Gazaryan IG, Zareen N, Yamashiro DJ, Willis DE, Ratan RR.

A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.

Neurobiol Dis. 2013 Jan;49:13-21. doi: 10.1016/j.nbd.2012.08.016.

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Ratan Lab

PUBLICATION:

Journal Article

Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR.

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

J Neurosci. 2011 May 4;31(18):6858-70. doi: 10.1523/JNEUROSCI.0710-11.2011. Erratum in: J Neurosci. 2012 May 9;32(19):6743.

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Ratan Lab

PUBLICATION:

Journal Article

Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR.

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR.

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Akiba Y, Cave JW, Akiba N, Langley B, Ratan RR, Baker H.

Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):673-7. doi: 10.1016/j.bbrc.2010.02.054.

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Willis Lab / Ratan Lab

PUBLICATION:

Journal Article

Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B.

HDAC6 is a target for protection and regeneration following injury in the nervous system.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. doi: 10.1073/pnas.0907935106.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Review

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR.

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345 . Review.

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Cho Lab / Ratan Lab

PUBLICATION:

Journal Article

Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR.

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.

J Neurosci. 2008 Jan 2;28(1):163-76. doi: 10.1523/JNEUROSCI.3200-07.2008.

Full-Text on PubMed

Ratan Lab / Cho Lab

PUBLICATION:

Review

Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J.

Harnessing hypoxic adaptation to prevent, treat, and repair stroke.

J Mol Med (Berl). 2007 Dec;85(12):1331-8. Review.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Review

Langley B, Gensert JM, Beal MF, Ratan RR.

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):41-50. Review.

Abstract on PubMed

Ratan Lab

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