Publications for Huanlian (Lian) Chen, M.S. | Burke Neurological Institute

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Publications for Huanlian (Lian) Chen, M.S.

Showing 1 - 17 of 17 total

PUBLICATION:

Journal Article

Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang & Gary E. Gibson

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Nat Commun. 2022 Jan 10;13(1):159. doi: 10.1038/s41467-021-27572-2.

Open Access on Nature

PUBLICATION:

Journal Article

Lidan Sun, Ruchika Bhawal, Hui Xu, Huanlian Chen, Elizabeth T Anderson, Vahrum Haroutunian, Abigail C Cross, Sheng Zhang, Gary E Gibson

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease

J Neurochem. 2021 Jul;158(2):282-296. doi: 10.1111/jnc.15377. Epub 2021 May 12.

Abstract on PubMed

PUBLICATION:

Manuscript

Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial

J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.

Full-Text on Pubmed

PUBLICATION:

Journal Article

Huanlian Chen, Abigail C Cross, Ankita Thakkar, Hui Xu, Aiqun Li, Dan Paull, Scott A Noggle, Laken Kruger, Travis T Denton, Gary E Gibson

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

J Neurochem. 2021 Mar;156(6):867-879. doi: 10.1111/jnc.15160. Epub 2020 Sep 12.

Abstract on PubMed

PUBLICATION:

Journal Article

Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE.

Mild metabolic perturbations alter succinylation of mitochondrial proteins.

J Neurosci Res. 2017 Jun 20. doi: 10.1002/jnr.24103. [Epub ahead of print]

Abstract on PubMed

PUBLICATION:

Journal Article

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.

Abstract on PubMed

Cho Lab / Gibson Lab

PUBLICATION:

Journal Article

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE.

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.

Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23.

Abstract on PubMed

PUBLICATION:

Journal Article

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S.

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096.

Full Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Gibson GE.

Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry.

Metab Brain Dis. 2014 Dec;29(4):1083-93. doi: 10.1007/s11011-014-9541-4.

Full-Text on PubMed

PUBLICATION:

Journal Article

Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q.

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.

Neurobiol Aging. 2012 Jun;33(6):1121.e13-24. doi: 10.1016/j.neurobiolaging.2011.11.003.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Gibson GE.

Thiamine and oxidants interact to modify cellular calcium stores.

Neurochem Res. 2010 Dec;35(12):2107-16. doi: 10.1007/s11064-010-0242-z.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE.

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Neurochem Int. 2009 Feb;54(2):111-8. doi: 10.1016/j.neuint.2008.10.008.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE.

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

Neurobiol Aging. 2009 Oct;30(10):1587-600. doi: 10.1016/j.neurobiolaging.2007.12.013.

Full-Text on PubMed

PUBLICATION:

Journal Article

Karuppagounder SS, Xu H, Pechman D, Chen LH, DeGiorgio LA, Gibson GE.

Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism.

Neurochem Res. 2008 Jul;33(7):1365-72. doi: 10.1007/s11064-008-9594-z.

Full-Text on PubMed

PUBLICATION:

Journal Article

Shi Q, Karuppagounder SS, Xu H, Pechman D, Chen H, Gibson GE.

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.

Neurochem Int. 2007 Jun;50(7-8):921-31.

Full-Text on PubMed

PUBLICATION:

Journal Article

Huang HM, Chen HL, Xu H, Gibson GE.

Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease.

Free Radic Biol Med. 2005 Oct 15;39(8):979-89.

Abstract on PubMed

PUBLICATION:

Journal Article

Shi Q, Chen HL, Xu H, Gibson GE.

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

J Biol Chem. 2005 Mar 25;280(12):10888-96.

Abstract on PubMed