Publications for Amit Kumar, Ph.D.

Showing 1 - 16 of 16 total

PUBLICATION:

Journal Article

Amit Kumar, Saravanan S Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-Li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H Geschwind, Rajiv R Ratan

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience

Neuron . 2023 Jul 11;S0896-6273(23)00472-5. doi: 10.1016/j.neuron.2023.06.013. Online ahead of print.

Full Text on Neuron

Ratan Lab

PUBLICATION:

Journal Article

Amit Kumar, Saravanan S. Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T. Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H. Geschwind, Rajiv R. Ratan

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience

Science Direct 14 July 2023

Full Text on Science Direct

Ratan Lab

PUBLICATION:

Journal Article

Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S. Karuppagounder, Rajiv R. Ratan

A STING agonist preconditions against ischaemic stroke via an adaptive antiviral Type 1 interferon response

Brain Commun. 2022 May 24;4(3):fcac133. doi: 10.1093/braincomms/fcac133. eCollection 2022.

PDF on Oxford Academic

Ratan Lab

PUBLICATION:

Manuscript

Marietta Zille, Juan A Oses-Prieto, Sara R Savage, Saravanan S Karuppagounder, Yingxin Chen, Amit Kumar, John H Morris, Karl A Scheidt, Alma L Burlingame, Rajiv R Ratan

Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis

J Neurosci. 2022 Mar 9;42(10):2065-2079. doi: 10.1523/JNEUROSCI.0923-20.2021. Epub 2022 Jan 5.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Manuscript

Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan

HIF1α stabilization in hypoxia is not oxidant-initiated

Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873.

Full-Text on Pubmed

Ratan Lab

PUBLICATION:

Review

Orjon Rroji, Amit Kumar, Saravanan S Karuppagounder, Rajiv R Ratan

Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases

Neurobiol Dis. 2021 Jan;147:105145. doi: 10.1016/j.nbd.2020.105145. Epub 2020 Oct 28.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan

Tilorone, an oral antiviral agent utilized in humans, preconditions against transient ischemia in mice

Conditioning Medicine 2020. 3(1): 1-8.

Full-Text on Conditioning Medicine

Ratan Lab / Yoshida Lab

PUBLICATION:

Opinion Article

Kumar A. Edited by Rajiv R. Ratan and Yutaka Yoshida

Sugar as a therapeutic target for the cognitive restoration following traumatic brain injury.

Curr Opin Neurol . 2019 Dec;32(6):815-821. doi: 10.1097/WCO.0000000000000752.

Abstract on PubMed

PUBLICATION:

Review

Kumar A, Kitago T.

Pharmacological Enhancement of Stroke Recovery

Curr Neurol Neurosci Rep. 2019 May 30;19(7):43. doi: 10.1007/s11910-019-0959-2.

Abstract on PubMed

Ratan Lab / Willis Lab

PUBLICATION:

Manuscript

Marietta Zille, Amit Kumar, Nandini Kundu, Megan W. Bourassa, Victor S. C. Wong, Dianna Willis, Saravanan S. Karuppagounder and Rajiv R. Ratan

Ferroptosis in neurons and cancer cells is similar but differentially regulated by histone deacetylase inhibitors

eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.

Full-Text on Pubmed

Ratan Lab

PUBLICATION:

Journal Article

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S8, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.

Full-Text on Pubmed

Ratan Lab

PUBLICATION:

Journal Article

Kumar A, Ratan RR.

Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.

J Huntingtons Dis. 2016 Oct 1;5(3):217-237.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Review

Karuppagounder SS, Kumar A, Shao DS, Zille M, Bourassa MW, Caulfield JT, Alim I, Ratan RR.

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases.

Brain Res. 2015 Dec 2;1628(Pt B):273-87. doi: 10.1016/j.brainres.2015.07.030. Review.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR.

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Review

Kumar A, Vaish M, Ratan RR.

Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis.

Drug Discov Today. 2014 Jul;19(7):956-62. doi: 10.1016/j.drudis.2014.03.016. Review.

Full-Text on PubMed

Ratan Lab

PUBLICATION: