Metabolic Vulnerabilities & Opportunities in Brain Function

EVENT:

Weekly Seminar | Not Open to the Public

Host:

Gary E. Gibson, Ph.D.

Who Should Attend:

Researchers

Event Flyer:

ryan_1-21-25.pdf

Speakers

Timothy A. Ryan, Ph.D.

Tri-Institutional Professor

Department of Biochemistry

Weill Cornell Medicine

Research

The Ryan laboratory develops and applies quantitative methods to understand the molecular underpinnings of synapse function with a particular emphasis on the control of neurotransmitter release and the recycling of synaptic vesicles. The lab discovered that nerve terminals represent one of the critical loci of metabolic vulnerability in the brain which has led them to explore questions of how fuel availability and combustion is regulated to support synapse function.

Publications

Lorena Benedetti, Ruolin Fan, Aubrey V Weigel, Andrew S Moore, Patrick R Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M Hubbard, Song Pang, C Shan Xu, Harald F Hess, Stephan Saalfeld, Vidhya Rangaraju, David E Clapham, Pietro De Camilli, Timothy A Ryan, Jennifer Lippincott-Schwartz

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Science Direct

A. C. Kokotos, A.M. Antoniazzi, S.R. Unda, M. Soo Ko, D. Park, D. Eliezer, M. G. Kaplitt, P. De Camilli, T.A. Ryan.

Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits

Science Advances

J. S. Marvin, A. C. Kokotos, M. Kumar, C. Pulido, A. N. Tkachuk, J. Shuxin Yao. T. A. Brown & T. A. Ryan. iATPSnFR2

iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP

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Metabolic Vulnerabilities & Opportunities in Brain Function

Speakers

Research

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