Lysosome Dysfunction- a primary catalyst and driver of Alzheimer’s Disease

Abstract

The genetics underlying early-onset AD have long been viewed as uniquely supporting the sole primary role of abeta in AD pathogenesis. Evidence will be presented that the endosomal- lysosomal-autophagy network (ELA) is an equally compelling primary target of causative and risk AD genes. I will discuss the molecular and cellular underpinnings of this role that make ELA disruption an essential partner with APP metabolites in instigating and driving disease pathogenesis.