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Acupuncture Modulates Systemic Inflammation by Driving Somatosensory Autonomic Pathways

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Speakers

Qiufu Ma's Photo
Professor
Department of Neurobiology

Abstract

Acupuncture has been used to treat human diseases for thousands of years, but the underlying mechanisms are poorly understood. Here we used genetic tools to manipulate somatosensory and autonomic neurons, and showed that electroacupuncture can drive various somato-autonomic pathways in a body region- and stimulation intensity-dependent manner. Using cytokine release syndromes induced by bacterial endotoxins as the experimental model, we further showed that electroacupuncutre can modulate sysemic inflammation in a disease state-dependent manner. Our studies could help to optimize electric stimulation parameters to treat severe systemic inflammation, whose management remains a major medical challenge.

Qiufu Ma's Figure

Publications

Shenbin Liu, Zhi-Fu Wang, Yang-Shuai Su, Russell S Ray, Xiang-Hong Jing, Yan-Qing Wang, Qiufu Ma
Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture
Neuron. 2020 Nov 11;108(3):436-450.e7. doi: 10.1016/j.neuron.2020.07.015. Epub 2020 Aug 12.
Tianwen Huang, Shing-Hong Lin, Nathalie M Malewicz, Yan Zhang, Ying Zhang, Martyn Goulding, Robert H LaMotte, Qiufu Ma
Identifying the pathways required for coping behaviours associated with sustained pain
Nature. 2019 Jan;565(7737):86-90. doi: 10.1038/s41586-018-0793-8. Epub 2018 Dec 10.
Longzhen Cheng, Bo Duan, Tianwen Huang, Yan Zhang, Yangyang Chen, Olivier Britz, Lidia Garcia-Campmany, Xiangyu Ren, Linh Vong, Bradford B Lowell, Martyn Goulding, Yun Wang, Qiufu Ma
Identification of spinal circuits involved in touch-evoked dynamic mechanical pain
Nat Neurosci. 2017 Jun;20(6):804-814. doi: 10.1038/nn.4549. Epub 2017 Apr 24.

When

Tuesday, June 22, 2021 - 12:30pm

Where

Conference Room: 
Online Webinar

More Information

Darlene White

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