Gibson Lab
Research Projects

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Featured Clinical Trials

CLINICAL TRIAL: 
In-Progress / Currently Recruiting Participants
November 10, 2014 to November 1, 2019
Cognitive Recovery, Neurodegenerative Diseases

Research Projects

RESEARCH PROJECT: 
In Progress
Thiamine (vitamin B1) dependent processes are reduced in Alzheimer’s disease. Thiamine deficiency mimics many aspects of Alzheimer’s disease including the reduced glucose metabolism and exaggeration of the plaque and tangle pathology.
RESEARCH PROJECT: 
In Progress
We postulate that critical enzymes are modified post-translationally in Alzheimer’s disease. The focus is on the key mitochondrial enzyme alpha-ketoglutarate dehydrogenase complex (KGDHC).
RESEARCH PROJECT: 
In Progress
Reducing the enzyme KGHDC has widespread consequences on cell and brain function. We postulate this is because it is responsible for post-translation modification of thousands of proteins by succinylation.
RESEARCH PROJECT: 
In Progress
Alzheimer’s disease related changes in releasable internal calcium stores as well as in mitochondrial function have been suggested from animal studies and cultured cells from Alzheimer’s disease patients such as fibroblasts, and make good therapeutic targets.
RESEARCH PROJECT: 
In Progress

The investigators on the program project have two mechanisms for resource sharing.

RESEARCH PROJECT: 
In Progress

Mitochondrial dysfunction and oxidative stress are consistent features of multiple neurodegenerative diseases including Alzheimer’s disease (AD).

RESEARCH PROJECT: 
In Progress

Diminished brain metabolism and oxidative stress are characteristic features of Alzheimer's disease (AD). The mechanisms underlying these changes are as yet poorly defined.

RESEARCH PROJECT: 
In Progress
Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent mitochondrial enzymes that occur in brain in several common age-related neurodegenerative disorders.

Technologies

Western blots are used extensively to study post-translational modifications of the α-ketoglutarate dehydrogenase complex (KGDHC). The figure shows the separation of ketoglutarate dehydrogenase complex by blue-native gel.