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Stem Cells

Impact

PUBLICATION:

Journal Article

Huanlian Chen, Abigail C Cross, Ankita Thakkar, Hui Xu, Aiqun Li, Dan Paull, Scott A Noggle, Laken Kruger, Travis T Denton, Gary E Gibson

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

J Neurochem. 2021 Mar;156(6):867-879. doi: 10.1111/jnc.15160. Epub 2020 Sep 12.

Abstract on PubMed

PUBLICATION:

Manuscript

Goldberg DC, Fones L, Vivinetto AL, Caufield JT, Ratan RR, Cave JW.

Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands

ACS Chem Neurosci. 2020 May 20;11(10):1504-1518. doi: 10.1021/acschemneuro.0c00194. Epub 2020 Apr 29.

Abstract on PubMed

PUBLICATION:

Journal Article

Lauren N Miterko, Joshua J White, Tao Lin, Amanda M Brown, Kevin J O'Donovan, Roy V Sillitoe

Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

Neural Dev . 2019 Mar 12;14(1):6. doi: 10.1186/s13064-019-0130-4.

Full-Text on Pubmed

EVENT:

Weekly Seminar | Not Open to the Public

Influences of Neuronal Activity on Pain and Regeneration After Spinal Cord Injury

Tuesday, January 30, 2018 - 12:30pm

Billings Building – Rosedale

PRESENTATION:

Poster Presentation

November 11, 2017 to November 15, 2017

Dramatic changes in mitochondria and calcium homeostasis during differentiation of induced pluripotent stem cells.

Venue:

Society for Neuroscience Annual Meeting 2017

Featured Researchers:

Ankita Thakkar, Ph.D. / Huanlian (Lian) Chen, M.S. / Hui Xu, M.B. / Gary E. Gibson, Ph.D.

RESEARCH PROJECT:

In Progress

To Test Whether Changes in Metabolism and Calcium Regulation Seen in Animal Models or Peripheral Tissues form Alzheimer’s Disease Patients Occur in Human Neurons Derived from Inducible Pluripotent Stem Cells

Alzheimer’s disease related changes in releasable internal calcium stores as well as in mitochondrial function have been suggested from animal studies and cultured cells from Alzheimer’s disease patients such as fibroblasts, and make good therapeutic targets.

PUBLICATION:

Journal Article

Davis RJ, Alam NM, Zhao C, Müller C, Saini JS, Blenkinsop TA, Mazzoni F, Campbell M, Borden SM, Charniga CJ, Lederman PL, Aguilar V, Naimark M, Fiske M, Boles N, Temple S, Finnemann SC, Prusky GT, Stern JH.

The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue.

Stem Cell Reports. 2017 Jul 11;9(1):42-49. doi: 10.1016/j.stemcr.2017.05.016. Epub 2017 Jun 15.

Abstract on PubMed

PUBLICATION:

Review

Gibson GE, Thakkar A.

Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility.

Neurochem Int. 2017 Jun 13. pii: S0197-0186(17)30332-7. doi: 10.1016/j.neuint.2017.06.007. [Epub ahead of print]

Abstract on PubMed

PUBLICATION:

Journal Article

Huang S, O'Donovan KJ, Turner EE, Zhong J, Ginty DD.

Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation.

Elife. 2015 Sep 29;4:e10874. doi: 10.7554/eLife.10874.

Abstract on PubMed

PUBLICATION:

Journal Article

Pan L, North HA, Sahni V, Jeong SJ, Mcguire TL, Berns EJ, Stupp SI, Kessler JA.

β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.

PLoS One. 2014 Aug 6;9(8):e104335. doi: 10.1371/journal.pone.0104335. eCollection 2014.

Full-Text on Pubmed