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Cell Death

Impact

PUBLICATION: 
Journal Article
Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.
Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.
Abstract on PubMed
PUBLICATION: 
Journal Article
Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.
J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.
Abstract on PubMed
RESEARCH PROJECT: 
In Progress
Researchers have developed an in vitromodel to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors.
RESEARCH PROJECT: 
In Progress
Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and has the highest mortality rates among strokes with up to 50% within 30 days after the insult. It is known to increase intracranial pressure and is associated with excitotoxicity, oxidative stress, and inflammation.
PUBLICATION: 
Journal Article
Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.
Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.
Abstract on PubMed
GRANT: 
Federal
April 15, 2016 to March 31, 2021
Grant Number: 
P01AG014930
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Investigators: 
Project Leader
PUBLICATION: 
Journal Article
Toychiev AH, Ivanova E, Yee CW, Sagdullaev BT.
J Neurosci. 2013 Aug 28;33(35):13972-7. doi: 10.1523/JNEUROSCI.2399-13.2013.
Full-Text on PubMed
PUBLICATION: 
Journal Article
Ma TC, Langley B, Ko B, Wei N, Gazaryan IG, Zareen N, Yamashiro DJ, Willis DE, Ratan RR.
Neurobiol Dis. 2013 Jan;49:13-21. doi: 10.1016/j.nbd.2012.08.016.
Full-Text on PubMed
PUBLICATION: 
Review
Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF.
Biochim Biophys Acta. 2010 Jan;1802(1):122-34. doi: 10.1016/j.bbadis.2009.08.010. Review.
Full-Text on PubMed
PUBLICATION: 
Journal Article
Niatsetskaya Z, Basso M, Speer RE, McConoughey SJ, Coppola G, Ma TC, Ratan RR.
Antioxid Redox Signal. 2010 Apr;12(4):435-43. doi: 10.1089/ars.2009.2800.
Full-Text on PubMed