The Hollis lab studies the reorganization of neural circuits during learning and rehabilitation from injury. Our principal research focus is on the function of cortical motor networks after spinal cord injury. Our studies lie at the intersection of molecular biology and systems neuroscience, with an eye towards translation. We utilize optogenetic stimulation of, and optical recording from, cortical motor networks in order to understand the mechanisms that enable neural circuit remodeling after injury.
Dr. Hollis’ previous work demonstrated the role of circuit remodeling in promoting functional recovery of sensory and motor circuits after spinal cord injury. He demonstrated that cortical motor representations shift in response to rehabilitation and induced remodeling of the corticospinal circuit after injury. Our current work utilizes chemogenetic and optogenetic tools to investigate cortical plasticity and the integration of altered corticospinal circuits into a functional motor network.