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Metabolism

Impact

PUBLICATION: 
Journal Article
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang & Gary E. Gibson
Nat Commun. 2022 Jan 10;13(1):159. doi: 10.1038/s41467-021-27572-2.
Open Access on Nature
NEWS: 
Article
Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.
Gibson Team in the Lab
NEWS: 
Article
The research team examined how myeloid cells can also facilitate repair by clearing debris and promoting tissue remodeling during the early stages of repair. The study showed that a transcription factor, hypoxia-inducible factor, which the Ratan lab has been studying for years, marks myeloid cells that are associated with good long term recovery.
Photo of Raj, Saravanan, Amit, and Yingxin
PUBLICATION: 
Case Report
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing, MISTIE III Consortium, ICHseq investigators
Science Immunology 2021 Feb 19;6(56):eabd6279. doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19.
Full-Text on PMC
NEWS: 
In the Media
Media Outlet: 
CNN Health
Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.
Gibson Team in the Lab
NEWS: 
Article
A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).
Photo of Gibson Lab
PUBLICATION: 
Manuscript
Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti
J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.
Full-Text on Pubmed
EVENT: 
Weekly Seminar | Not Open to the Public
Tuesday, November 19, 2019 - 12:30pm
Billings Building – Rosedale
PUBLICATION: 
Opinion Article
Kumar A. Edited by Rajiv R. Ratan and Yutaka Yoshida
Curr Opin Neurol . 2019 Dec;32(6):815-821. doi: 10.1097/WCO.0000000000000752.
Abstract on PubMed
PUBLICATION: 
Opinion Article
Yoshida Y, Ratan RR.
Curr Opin Neurol. 2019 Oct 10. doi: 10.1097/WCO.0000000000000757. [Epub ahead of print]
Full-Text on Wolters Kluwer