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Metabolism

Impact

RESEARCH PROJECT: 
In Progress
Alzheimer’s disease related changes in releasable internal calcium stores as well as in mitochondrial function have been suggested from animal studies and cultured cells from Alzheimer’s disease patients such as fibroblasts, and make good therapeutic targets.
RESEARCH PROJECT: 
In Progress
Reducing the enzyme KGHDC has widespread consequences on cell and brain function. We postulate this is because it is responsible for post-translation modification of thousands of proteins by succinylation.
RESEARCH PROJECT: 
In Progress
Thiamine (vitamin B1) dependent processes are reduced in Alzheimer’s disease. Thiamine deficiency mimics many aspects of Alzheimer’s disease including the reduced glucose metabolism and exaggeration of the plaque and tangle pathology.
EVENT: 
Weekly Seminar
Tuesday, September 12, 2017 - 12:30pm
Billings Building – Rosedale
PUBLICATION: 
Journal Article
Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE.
J Neurosci Res. 2017 Jun 20. doi: 10.1002/jnr.24103. [Epub ahead of print]
Abstract on PubMed
PUBLICATION: 
Review
Gibson GE, Thakkar A.
Neurochem Int. 2017 Jun 13. pii: S0197-0186(17)30332-7. doi: 10.1016/j.neuint.2017.06.007. [Epub ahead of print]
Abstract on PubMed
PRESENTATION: 
Seminar
May 3, 2017
Venue: 
Montefiore Hudson Valley, Center of Excellence for Alzheimer’s Disease (CEAD), Bronx, NY
PUBLICATION: 
Journal Article
Gibson GE, Thakkar A.
Neurochem Res. 2017 Feb 8. doi: 10.1007/s11064-017-2182-3. [Epub ahead of print]
Abstract on PubMed