Ratan Lab
Research Projects

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Research Projects

RESEARCH PROJECT: 
In Progress
Researchers have developed an in vitromodel to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors.
RESEARCH PROJECT: 
In Progress
Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and has the highest mortality rates among strokes with up to 50% within 30 days after the insult. It is known to increase intracranial pressure and is associated with excitotoxicity, oxidative stress, and inflammation.
RESEARCH PROJECT: 
In Progress
Oxidative stress is an event associated with a variety of neurological disorders, including stroke. It occurs when neurons are unable to maintain reactive oxygen species (ROS) homeostasis.
RESEARCH PROJECT: 
In Progress
The human brain represents only 2% of the body weight but it utilizes around 20% of total body glucose. This shows how crucial glucose metabolism is for the proper functioning of neurons and other cell types in the brain.
RESEARCH PROJECT: 
In Progress
Histone deaceytlase (HDAC) inhibitors are a promising therapeutic of neurological diseases.