Ratan Lab
People

You are here

Saravanan S. Karuppagounder, Ph.D.
Saravanan S. Karuppagounder, Ph.D.
FACULTY - INSTRUCTOR

Saravanan S. Karuppagounder, Ph.D.

Director
Sperling Center for Hemorrhagic Stroke Recovery
Burke Medical Research Institute
Instructor of Neuroscience
Weill Cornell Medical College

Biography

My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

PUBLICATION: 
Journal Article
Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV.
Elife. 2016 Jun 2;5. doi:pii: e15092. 10.7554/eLife.15092.
Abstract on PubMed
PUBLICATION: 
Journal Article
Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.
Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.
Abstract on PubMed
PUBLICATION: 
Journal Article
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR
Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.
Abstract on PubMed