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Saravanan S. Karuppagounder, Ph.D.

Saravanan S. Karuppagounder, Ph.D.

Director of the Spinal Cord Injury Core
Burke Neurological Institute
Laboratory for Redox Biology and Neural Protection and Repair
Burke Neurological Institute
Instructor of Neuroscience
Weill Cornell Medicine


My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

Journal Article
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Cell. 2019 Apr 26. pii: S0092-8674(19)30327-7. doi: 10.1016/j.cell.2019.03.032. [Epub ahead of print]
Abstract on CellPress
Marietta Zille, Amit Kumar, Nandini Kundu, Megan W. Bourassa, Victor S. C. Wong, Dianna Willis, Saravanan S. Karuppagounder and Rajiv R. Ratan
eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.
Full-Text on Pubmed
Journal Article
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL8, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.
Ann Neurol. 2018 Oct 7. doi: 10.1002/ana.25356. [Epub ahead of print]
Full-Text on Wiley Online Library