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Saravanan S. Karuppagounder, Ph.D.
Saravanan S. Karuppagounder, Ph.D.
FACULTY - INSTRUCTOR

Saravanan S. Karuppagounder, Ph.D.

Instructor
Laboratory for Redox Biology and Neural Protection and Repair
Burke Medical Research Institute
Instructor of Neuroscience
Weill Cornell Medicine

Biography

My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

PUBLICATION: 
Journal Article
Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.
Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.
Abstract on PubMed
PUBLICATION: 
Journal Article
Smirnova NA, Kaidery NA, Hushpulian DM, Rakhman II, Poloznikov AA, Tishkov VI, Karuppagounder SS, Gaisina IN, Pekcec A, Leyen KV, Kazakov SV, Yang L, Thomas B, Ratan RR, Gazaryan IG.
Aging Dis. 2016 Dec 1;7(6):745-762. doi: 10.14336/AD.2016.0505. eCollection 2016 Dec.
Full-Text on PubMed
PUBLICATION: 
Journal Article
Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV.
Elife. 2016 Jun 2;5. doi:pii: e15092. 10.7554/eLife.15092.
Full-Text on PubMed