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Saravanan S. Karuppagounder, Ph.D.
FORMER FACULTY

Saravanan S. Karuppagounder, Ph.D.

Former Director
Spinal Cord Injury Core
Burke Neurological Institute
Laboratory for Neural Redox Biology and Homeostatic Transcription
Burke Neurological Institute
Former Assistant Professor of Research in Neuroscience
Weill Cornell Medicine

Biography

My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

PUBLICATION: 
Journal Article
Amit Kumar, Saravanan S Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-Li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H Geschwind, Rajiv R Ratan
Neuron . 2023 Jul 11;S0896-6273(23)00472-5. doi: 10.1016/j.neuron.2023.06.013. Online ahead of print.
Full Text on Neuron
PUBLICATION: 
Journal Article
Amit Kumar, Saravanan S. Karuppagounder, Yingxin Chen, Carlo Corona, Riki Kawaguchi, Yuyan Cheng, Mustafa Balkaya, Botir T. Sagdullaev, Zhexing Wen, Charles Stuart, Sunghee Cho, Guo-li Ming, Jürgen Tuvikene, Tõnis Timmusk, Daniel H. Geschwind, Rajiv R. Ratan
Science Direct 14 July 2023
Full Text on Science Direct
PUBLICATION: 
Journal Article
Brian T David, Jessica J Curtin, Jennifer L Brown, Kerri Scorpio, Veena Kandaswamy, David J C Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S Karuppagounder, Mariajose Metcalfe, John W Cave, Caitlin E Hill
Glia . 2023 Mar;71(3):648-666. doi: 10.1002/glia.24302. Epub 2022 Dec 24.
Full Text on Wiley