Gibson Lab
Impact

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The Tricarboxylic Acid (Tca) Cycle in Neurodegeneration

GRANT: 
Federal
April 15, 2016 to March 31, 2021
Grant Number: 
P01AG014930
Funding Agency: 
National Institutes of Health (NIH)
Funding Institute: 
National Institute on Aging (NIA)
Published Grant: 
NIH RePORT

Goals

The experiments will test the hypothesis that changes in the mitochondrial TCA cycle and the consequent downstream signaling changes are central to the disease process and provide a therapeutic target that is not responsive to mitogenic therapies. Successful completion of these studies will identify additional mechanisms to reverse the deficits and ameliorate the disease process.  

Investigators

Gary E. Gibson, Ph.D.
Lab Director
Laboratory for Mitochondrial Biology and Metabolic Dysfunction in Neurodegeneration
Role: 
Project Leader

Associated

Research Methods