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Molecular Studies

Impact

RESEARCH PROJECT: 
In Progress
The human brain represents only 2% of the body weight but it utilizes around 20% of total body glucose. This shows how crucial glucose metabolism is for the proper functioning of neurons and other cell types in the brain.
RESEARCH PROJECT: 
In Progress
Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and has the highest mortality rates among strokes with up to 50% within 30 days after the insult. It is known to increase intracranial pressure and is associated with excitotoxicity, oxidative stress, and inflammation.
RESEARCH PROJECT: 
In Progress
Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent mitochondrial enzymes that occur in brain in several common age-related neurodegenerative disorders.
RESEARCH PROJECT: 
In Progress

Diminished brain metabolism and oxidative stress are characteristic features of Alzheimer's disease (AD). The mechanisms underlying these changes are as yet poorly defined.

RESEARCH PROJECT: 
In Progress

Mitochondrial dysfunction and oxidative stress are consistent features of multiple neurodegenerative diseases including Alzheimer’s disease (AD).

RESEARCH PROJECT: 
In Progress

Because strategies that promote acute neuroprotection have not successfully translated into clinical practice, studies to understand repair/recovery mechanisms that promote functional recovery have emerged.

RESEARCH PROJECT: 
In Progress

The recurring failure to translate neuroprotective strategies in animal models into clinical settings prompted us to reevaluate existing preclinical stroke models.

RESEARCH PROJECT: 
In Progress

Stroke-induced brain injury has been viewed mainly from a neurocentric perspective, with much attention given to the primary injury site and its penumbra.

GRANT: 
Federal
April 15, 2016 to March 31, 2021
Grant Number: 
P01AG014930
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Investigators: 
GRANT: 
Federal
April 1, 2016 to March 31, 2021
Grant Number: 
R01EY026576
National Institutes of Health (NIH)
National Eye Institute (NEI)
Investigators: 
Principal Investigator