Molecular Studies

Impact

PRESENTATION:

Annual Meeting

November 1, 2018 to November 2, 2018

Molecular control over of corticospinal segmental connectivity: novel substrates for corticospinal plasticity and repair

Venue:

American Society of Neurorehabilitation Annual Meeting 2018, San Diego, CA

Featured Researchers:

Vibhu Sahni, Ph.D.

Ratan Lab

PUBLICATION:

Journal Article

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL8, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.

Full-Text on Pubmed

Ratan Lab

PRESENTATION:

Symposium

September 22, 2018

Novel Molecular and Clinical Paradigms to Cure Disability After Stroke: Have We Been Setting the Bar Too Low

Venue:

Translational Research in Stroke Initiative, Emory University

Featured Researchers:

Rajiv R. Ratan, M.D., Ph.D.

Willis Lab

PUBLICATION:

Journal Article

Gershoni-Emek N, Altman T, Ionescu A, Costa CJ, Gradus-Pery T, Willis DE, Perlson E.

Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS

Front Mol Neurosci. 2018 Sep 5;11:311. doi: 10.3389/fnmol.2018.00311. eCollection 2018.

Abstract on PubMed

Ratan Lab

NEWS:

Award

May 31, 2018

Dr. Ratan Accepts Invitation to Serve as a Member of the Neural Oxidative Metabolism and Death Study Section, Center for Scientific Review.

Nation Institutes of Health (NIH)

With great honor, Dr. Raj Ratan, executive director of Burke Neurological Institute, has been invited to serve as a member of the Neural Oxidative Metabolism and Death Study Section, Center for Scientific Review for the term beginning July 01, 2018 and ending June 30, 2024.

Ratan Lab

PUBLICATION:

Journal Article

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S8, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.

Full-Text on Pubmed

Gibson Lab

RESEARCH PROJECT:

In Progress

The Molecular Basis for the Alzheimer’s Disease Related Decline in Key Mitochondrial Enzymes Is Unknown

We postulate that critical enzymes are modified post-translationally in Alzheimer’s disease. The focus is on the key mitochondrial enzyme alpha-ketoglutarate dehydrogenase complex (KGDHC).

NEWS:

Press Release

July 19, 2017

Lowey Announces $3.1 Million in NIH Funding for Burke Medical Research Institute

National Institutes of Health’s (NIH) National Institute of Neurological Disorders and Stroke (NINDS)

White Plains, NY -- Congresswoman Nita Lowey (D-NY17/Rockland-Westchester) today announced $3,125,875 in federal funding over the next five years for Burke Medical Research Institute (BMRI) in White Plains.