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Molecular Studies

Impact

RESEARCH PROJECT: 
In Progress
Our objective is to understand how axonal transport and local protein synthesis contribute to hyperexcitability exhibited by damaged neurons leading to neuropathic pain states.
RESEARCH PROJECT: 
In Progress
Oxidative stress is an event associated with a variety of neurological disorders, including stroke. It occurs when neurons are unable to maintain reactive oxygen species (ROS) homeostasis.
RESEARCH PROJECT: 
In Progress
The human brain represents only 2% of the body weight but it utilizes around 20% of total body glucose. This shows how crucial glucose metabolism is for the proper functioning of neurons and other cell types in the brain.
RESEARCH PROJECT: 
In Progress
Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and has the highest mortality rates among strokes with up to 50% within 30 days after the insult. It is known to increase intracranial pressure and is associated with excitotoxicity, oxidative stress, and inflammation.
RESEARCH PROJECT: 
In Progress

Understanding the basic biology behind dystrophic axonal endings (retraction bulbs) that form when injured axons encounter the chronic lesion margin.

RESEARCH PROJECT: 
In Progress
Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent mitochondrial enzymes that occur in brain in several common age-related neurodegenerative disorders.
RESEARCH PROJECT: 
In Progress

Diminished brain metabolism and oxidative stress are characteristic features of Alzheimer's disease (AD). The mechanisms underlying these changes are as yet poorly defined.

RESEARCH PROJECT: 
In Progress

Mitochondrial dysfunction and oxidative stress are consistent features of multiple neurodegenerative diseases including Alzheimer’s disease (AD).

RESEARCH PROJECT: 
In Progress

Because strategies that promote acute neuroprotection have not successfully translated into clinical practice, studies to understand repair/recovery mechanisms that promote functional recovery have emerged.

RESEARCH PROJECT: 
In Progress

The recurring failure to translate neuroprotective strategies in animal models into clinical settings prompted us to reevaluate existing preclinical stroke models.