Hollis Lab
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Motor learning mechanisms during rehabilitation from spinal cord injury

GRANT: 
Non-Federal
September 1, 2017 to August 31, 2020
Grant Number: 
DOH01-FLLOW2-2016-00006
Funding Agency: 
New York State Department of Health (NYSDOH)
Funding Institute: 
Spinal Cord Injury Research Board (SCIRB)

Goals

The motor cortex is the region of the brain responsible for controlling voluntary motor movements. It contains somewhat fluid maps of the body that change in response to the learning of skilled behavior (ie. playing piano). As these skills are learned, the motor cortex refines the patterns of neuronal activity required for performing these complex tasks. Release of the neurotransmitter acetylcholine into the motor cortex regulates both the refinement of these motor maps and the learning of motor skills. It does so by changing the connections between neurons in the motor cortex. Spinal cord injury that affects output from the motor cortex disrupts these maps, while targeted rehabilitation from spinal cord injury leads to improved recovery of motor skill and maps. I propose to test the role that acetylcholine signaling plays in rehabilitation-mediated recovery from spinal cord injury. These findings will provide new opportunities for pharmacological modulation and for combinatorial treatments that support the recovery of corticospinal circuit function after injury. Additionally, acetylcholine synthesis decreases with age, so these studies could potentially have broad implications in rehabilitation for an aging US population that has shown a parallel increase in age at time of spinal cord injury.

Investigators

Yue Li, Ph.D.
Postdoctoral Fellow
Circuit Repair Laboratory
Role: 
Principal Investigator
Edmund Hollis II, Ph.D.
Lab Director
Circuit Repair Laboratory
Assistant Professor
Role: 
Mentor

Associated

Research Methods