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John W. Cave, Ph.D.

John W. Cave, Ph.D.

Lab Director
Laboratory for Neuronal Specification
Burke Neurological Institute
Assistant Professor
Weill Cornell Medicine


John graduated from Kenyon College with a degree in Chemistry. Under the supervision of Dr. David Wemmer, he earned a doctoral degree in Chemistry studying protein structure and dynamics by solution nuclear magnetic resonance at the University of California at Berkeley. Several of the proteins he studied during his graduate training were gene transcription regulatory factors, which spurred an interest in the developmental role played by these proteins.

Pursuing this interest, John joined the Burke Medical Research Institute as a post-doctoral fellow to investigate gene transcription regulatory mechanisms mediated by the Notch signaling pathway that are necessary for neural precursor cell development inĀ Drosophila melanogaster. In 2006, he became an Instructor at the Burke Medical Research Institute and Weill Cornell Medical College Department of Neurology and Neuroscience. John collaborated with Dr. Harriet Baker to study specification of the dopaminergic neuronal phenotype in the mammalian olfactory bulb.

In 2012, John was promoted to Assistant Professor at the Burke Medical Research Institute and Weill Cornell Medical College Department of Neurology and Neuroscience. His laboratory is interested in elucidating the molecular mechanisms that establish the diversity of neuronal phenotypes in brain. The laboratory is currently focused on the regulation of neural stem cell differentiation in the post-natal and adult subventricular zone.


Postdoctoral Fellowship
Burke Neurological Institute, White Plains, New York
Ph.D., Chemistry
University of California at Berkeley
A.B., Chemistry
Kenyon College, Gambier, Ohio

Recent Publications

Journal Article
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Cell. 2019 Apr 26. pii: S0092-8674(19)30327-7. doi: 10.1016/j.cell.2019.03.032. [Epub ahead of print]
Abstract on CellPress
Cave JW, Wickiser JK, Mitropoulos AN.
Biosens Bioelectron. 2018 Aug 27. pii: S0956-5663(18)30670-5. doi: 10.1016/j.bios.2018.08.063. [Epub ahead of print]
Abstract on PubMed
Journal Article
Ding B, Dobner PR, Mullikin-Kilpatrick D, Wang W, Zhu H, Chow CW, Cave JW, Gronostajski RM, Kilpatrick DL.
Mol Biol Cell. 2018 Apr 15;29(8):975-987. doi: 10.1091/mbc.E16-08-0595. Epub 2018 Mar 30.
Full-Text on Pubmed