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Understanding the Multicellular Response to Injury in the Mouse Spinal Cord

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Abstract 

Our lab studies the mechanisms of axon regeneration and sprouting after central nervous system (CNS) injury using mouse models of spinal cord injury. We started with the myelin-derived inhibitors and recently shifted focus to neuron-intrinsic pathways such as Pten/mTOR and MAP3Ks. We documented an age-dependent decline in axon regeneration and illustrated a multicellular role for the MAP3K12/13 pathway after CNS injury. Our in vivo imaging data supports a synaptic suppression hypothesis of axon regeneration.

Dr. Binhai Zheng's Figure

Publications

Lorenzana AO, Lee JK, Mui M, Chang A, Zheng B.
A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord.
Neuron. 2015 May 20;86(4):947-954. doi: 10.1016/j.neuron.2015.03.061. Epub 2015 Apr 30.
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B.
Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System.
Cell Rep. 2016 Apr 12;15(2):238-46. doi: 10.1016/j.celrep.2016.03.028. Epub 2016 Mar 31.
Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B.
Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS.
Cell Rep. 2018 Mar 27;22(13):3587-3597. doi: 10.1016/j.celrep.2018.02.102.

When

Tuesday, November 12, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Research Methods