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Uncovering Mechanisms of Neurodegeneration with Intravital Optical Imaging

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Speakers

Guest Speaker
Dr. Jaime Grutzendler's Photo
Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience
Vice-Chair for Basic Research

Abstract 

The dynamics and logic of neuro-glio-vascular interactions in health and disease

Our knowledge about the complex interplay between the various brain cells types (neuronal and non-neuronal) is still rudimentary. These interactions are disrupted in every neurological disorder. Our laboratory is interested in elucidating these multicellular and complex interactions that occur during brain pathogenesis. Recent innovations in live imaging and optical probes are allowing sophisticated interrogation of the structural and functional cellular changes that occur in pathological processes. Our goal is to develop and implement such methodologies for advancing our understanding of the physiology of different brain cells and how they interact in their native unperturbed microenvironment and during homeostatic perturbations. Our lab uses a variety of techniques including two-photon microscopy to repeatedly image individual neurons, glial cells (microglia, astrocytes, pericytes) and blood vessels over periods of up to months. We also developed a methodology for in vivo label free microscopy of myelin to study axonal myelination. This imaging-centric approach is combined with the use of viral vectors and in utero electroporation, optical sensors of cellular physiology, optogenetics, chemogenetics and genome editing techniques. Specific disease conditions that we are interested in include: Alzheimer’s, microvascular and myelin pathologies.

Dr. Jaime Grutzendler's Figure

Publications

Hill RA, Li AM, Grutzendler J
Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain.
Nat Neurosci. 2018 May;21(5):683-695. doi: 10.1038/s41593-018-0120-6. Epub 2018 Mar 19.
Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Neuron. 2016 May 18;90(4):724-39. doi: 10.1016/j.neuron.2016.05.003.
Condello C, Yuan P, Grutzendler J.
Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.
Biol Psychiatry. 2018 Feb 15;83(4):377-387. doi: 10.1016/j.biopsych.2017.10.007. Epub 2017 Oct 14.

When

Tuesday, September 24, 2019 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria