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Spinal Cord Injury - Induced Immunodeficiency: Experimental Evidence and Clinical Relevance

Weekly Seminar
Who Should Attend: 


Guest Speaker
Jan Schwab, M.D., Ph.D.
Department of Neurology
Ohio State University - College of Medicine


Spinal cord injury (SCI) affects the normally well-balanced interplay of the two supersystems: the nervous and the immune system. Recent research elucidated some of the involved signals and mechanisms and, importantly, was able to demonstrate that CNS-immune interactions are highly relevant for functional outcome after SCI. SCI-induced immunodeficiency (SCI-IDS) increases the susceptibility to infection, the most relevant complication in SCI patients. Evidence from large multi-center cohort studies demonstrate that hospital-acquired infections such as pneumonia and wound infections are independent risk factors for poor neurological and functional recovery as well as for higher mortality. Acquired infections constitute a clinically relevant and treatable target for protecting the limited endogenous functional regeneration capacity.

Jan Schwab, M.D., Ph.D. Figure


Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM.
Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.
Nat Neurosci. 2017 Nov;20(11):1549-1559. doi: 10.1038/nn.4643. Epub 2017 Sep 18.
Kopp MA, Watzlawick R, Martus P, Failli V, Finkenstaedt FW, Chen Y, DeVivo MJ, Dirnagl U, Schwab JM.
Long-term functional outcome in patients with acquired infections after acute spinal cord injury.
Neurology. 2017 Feb 28;88(9):892-900. doi: 10.1212/WNL.0000000000003652. Epub 2017 Jan 27.
Brommer B, Engel O, Kopp MA, Watzlawick R, Müller S, Prüss H, Chen Y, DeVivo MJ, Finkenstaedt FW, Dirnagl U, Liebscher T, Meisel A, Schwab JM.
Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.
Brain. 2016 Mar;139(Pt 3):692-707. doi: 10.1093/brain/awv375. Epub 2016 Jan 10.


Tuesday, June 12, 2018 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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