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Recovery of Function after Severe Spinal Cord Injuries: Plasticity, Neuroregeneration and Neurorehabilitation

Weekly Seminar
Who Should Attend: 


Guest Speaker
Ronaldo M. Ichiyama, Ph.D.
Associate Professor in Motor Control
School of Biomedical Sciences, Faculty of Biological Sciences
University of Leeds


Our work focuses on understanding and enhancing activity-driven plasticity within the lumbar spinal cord that leads to recovery of locomotor function after severe SCI. We demonstrated that using a combination of pharmacological and epidural electrical stimulation of the lumbar spinal cord leads to recovery of stepping ability even after complete transection of the cord. The neural mechanisms underlying such recovery are still not well understood. We have also investigated the effectiveness of combining rehabilitation and neuromodulation strategies with other plasticity enhancing interventions such as anti-Nogo-A antibody, chondroitinase ABC, etc. Our results demonstrate that when plasticity is enhanced following SCI it is necessary to combine activity to drive functional recovery positively. We have reported surprising deficits in function when two individually positive interventions were combined.

Ronaldo M. Ichiyama, Ph.D. Figure


Smith CC, Paton JFR, Chakrabarty S, Ichiyama RM.
Descending Systems Direct Development of Key Spinal Motor Circuits.
J Neurosci. 2017 Jun 28;37(26):6372-6387. doi: 10.1523/JNEUROSCI.0149-17.2017. Epub 2017 Jun 2.
Chen K, Marsh BC, Cowan M, Al'Joboori YD, Gigout S, Smith CC, Messenger N, Gamper N, Schwab ME, Ichiyama RM.
Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats.
Exp Neurol. 2017 Jun;292:135-144. doi: 10.1016/j.expneurol.2017.03.012. Epub 2017 Mar 21.
Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.
Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury.
Brain. 2009 Jun;132(Pt 6):1426-40. doi: 10.1093/brain/awp085. Epub 2009 Apr 16.


Tuesday, June 5, 2018 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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