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Intrinsic Mechanisms for Cerebral Ischemic Tolerance

Weekly Seminar
Who Should Attend: 


Guest Speaker
Miguel A. Perez-Pinzon, Ph.D.
Professor of Neurology
Neuroscience Program
Vice-Chair for Basic Science
Director, Cerebral Vascular Disease Research Laboratories

My main research expertise is in the area of cerebral ischemia, which results from cardiac arrest or a stroke. My research focuses on the areas of synaptic, vascular and mitochondrial dysfunction that ensue following cerebral ischemia. Over the last 22 years, my laboratory has investigated the signaling pathways that lead to neuroprotection against ischemia following ischemic preconditioning (IPC). Another major emphasis has been our work in cardiac arrest and its devastating effect on hippocampal pathology. Our overall goal is to develop new therapies for pre- and post-treatment in stroke and cardiac arrest patients.

Miguel A. Perez-Pinzon, Ph.D. Figure


Stradecki-Cohan HM, Youbi M, Cohan CH, Saul I, Garvin AA, Perez E, Dave KR, Wright CB, Sacco RL, Perez-Pinzon MA.
Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia.
Stroke. 2017 Aug;48(8):2306-2309. doi: 10.1161/STROKEAHA.117.017296. Epub 2017 Jun 29.
Koronowski KB, Khoury N, Saul I, Loris ZB, Cohan CH, Stradecki-Cohan HM, Dave KR, Young JI, Perez-Pinzon MA.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Stroke. 2017 Nov;48(11):3117-3125. doi: 10.1161/STROKEAHA.117.018562. Epub 2017 Oct 10.
Cohan CH, Stradecki-Cohan HM, Morris-Blanco KC, Khoury N, Koronowski KB, Youbi M, Wright CB, Perez-Pinzon MA.
Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization.
J Cereb Blood Flow Metab. 2017 Dec;37(12):3774-3788. doi: 10.1177/0271678X17712178. Epub 2017 Jun 6.


Tuesday, April 24, 2018 - 3:00pm


785 Mamaroneck Avenue
White Plains, CA 10605
United States
Conference Room: 
Billings Building – Rosedale

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