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Experience-driven Competition in Neural Reorganization After Stroke

EVENT: 
Weekly Seminar
Who Should Attend: 
Researchers

Speakers

Guest Speaker
Theresa A. Jones, Ph.D.
Professor
Psychology Department & Neuroscience Institute

Abstract

Stroke instigates a prolonged period of neuroanatomical reorganization that is extraordinarily sensitive to behavioral experience. This talk focuses on findings from rodent stroke models that support critical roles for experience in shaping this process of reorganization. Behavioral interventions, such as rehabilitative training, can interact with regenerative responses to drive brain reorganization in functionally beneficial directions. However, "self-taught" compensatory behaviors may normally dominate experience-driven patterns of reorganization, and they can drive neural reorganization patterns that are suboptimal for outcome and competitive with those mediating rehabilitative training efficacy.

Dr. Theresa A. Jones Figure

Publications

Kim SY, Hsu JE, Husbands LC, Kleim JA, Jones TA.
Coordinated Plasticity of Synapses and Astrocytes Underlies Practice-Driven Functional Vicariation in Peri-Infarct Motor Cortex.
J Neurosci. 2018 Jan 3;38(1):93-107. doi: 10.1523/JNEUROSCI.1295-17.2017. Epub 2017 Nov 13.
Jones TA.
Motor compensation and its effects on neural reorganization after stroke.
Nat Rev Neurosci. 2017 May;18(5):267-280. doi: 10.1038/nrn.2017.26. Epub 2017 Mar 23.
Kim SY, Allred RP, Adkins DL, Tennant KA, Donlan NA, Kleim JA, Jones TA.
Experience with the "good" limb induces aberrant synaptic plasticity in the perilesion cortex after stroke.
J Neurosci. 2015 Jun 3;35(22):8604-10. doi: 10.1523/JNEUROSCI.0829-15.2015.

When

Tuesday, May 8, 2018 - 12:30pm

Where

785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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